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- W4297883911 abstract "Abstract Genistien is a soy isoflavone phytoestrogen, BCS class IV drug that has been efficacious for treatment of melanoma. Therefore, prepared Genistien loaded nanostructured lipid carriers (GEN-NLCs) for controlled and target delivery to melanoma cells. GEN-NLCs were formulated by solvent diffusion method applied Thogonal Taguchi optimization. Prepared GEN-NLCs were characterized by their physicochemical quality like particle size, zeta potential, morphology (SEM and AFM), entrapment efficiency, in-vitro release, and incompatibility studied such as DSC, and XRD. In-vitro anticancer and cellular uptake studies were accomplished in MTT assay method and A-375 melanoma cell-line by fluorescence-microscopy technique. Nanogel was prepared by incorporating optimized batch of GEN-NLC in methocel and evaluated for particle size and mechanical properties, In-vitro and ex- vivo occlusion studies, in-vitro release and ex-vivo human cadaver skin permeation and retention studies. Prepared GEN-NLCs were found to be a smooth surface with particle size 189.90±2.45 nm, 89.50±4.52% EE, -14.98±1.4mV zeta potential, and sustained release. MTT assay revealed that nanoparticles were 15.37 times more effective against melanoma as compared to pristine drugs. There was no significant change in texture profile of nanogel after incorporating GEN-NLC. Moreover, a significant increase in occlusivity was observed with occlusion factor almost 3.75 times more than control gel at end of 24 h. Ex-vivo studies further confirmed decrease in flux across skin i.e. sustained release pattern of GEN from hydrogel and increased hydration and retention in epidermis. Therefore, topical delivery of GEN-NLC loaded gel showed potential delivery system to target skin epidermis for melanoma cancer cells with enhanced efficacy." @default.
- W4297883911 created "2022-10-01" @default.
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- W4297883911 date "2022-09-12" @default.
- W4297883911 modified "2023-09-28" @default.
- W4297883911 title "Optimization, Evaluation and Delivery of Genistein Loaded Long Circulating Nanostructured Lipid Carriers for Treatment of Cancer Melanoma Cells" @default.
- W4297883911 doi "https://doi.org/10.21203/rs.3.rs-2042700/v1" @default.
- W4297883911 hasPublicationYear "2022" @default.
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