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• W4297884502 abstract "Abstract Objective : To highlight the potential importance of confocal microscopy (IVCM) in the follow-up of patients with refractory multiple myeloma treated with Belantamab Mafodotin. Methods : A retrospective case series of 8 patients with refractory multiple myeloma treated with belantamab mafodotin was reported. Ophthalmologic follow-up of these patients every 3 weeks before each new infusion included systematic corneal examination with IVCM. A complementary analysis of the morphological data collected in IVCM was performed to evaluate the density, the average size and the circularity of the lesions observed. Results : In case 1, the iatrogenic damage was maximal at the 6th week of follow-up with an important damage of Bowman's layer, leading to the suspension of the treatment. After resumption of treatment at a reduced dosage, the morphological damage to the cornea was reduced. In case 2, the onset of iatrogenic damage related to the treatment was observed but the follow-up was interrupted early because of therapeutic escape of the disease. In case 3, a prolonged follow-up could be performed showing a good tolerance to the treatment. In case 4, a decrease in visual acuity was observed at the 6th week of follow-up in connection with the treatment-related toxicity well observed in IVCM. Follow-up was then interrupted due to therapeutic escape of the disease. In cases 5 and 6, a significant decrease in visual acuity was observed at the 6th week in relation to iatrogenic morphological anomalies of the central cornea. The resumption of treatment at a reduced dosage was accompanied by an improved tolerance. In cases 7 and 8, the patients did not develop specific damage. Conclusion : Our study showed the interest of corneal morphological follow-up in IVCM in patients treated with belantamab mafodotin in order to detect early signs of corneal iatrogenicity and to guide the management accordingly, before the suspension of treatment." @default.
• W4297884502 created "2022-10-01" @default.
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• W4297884502 date "2022-09-20" @default.
• W4297884502 modified "2023-10-17" @default.
• W4297884502 title "Corneal iatrogenicity of Belantamab Mafodotin (GSK2857916), Clinical and Morphological In Vivo Confocal Microscopy follow-up of a case series" @default.
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• W4297884502 doi "https://doi.org/10.21203/rs.3.rs-2065466/v1" @default.
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