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• W4297904506 endingPage "444" @default.
• W4297904506 startingPage "411" @default.
• W4297904506 abstract "Alzheimer's disease (AD) is currently the third most progressive neurodegenerative disorder people facing across globally. The brains of AD patients undergo significant changes because of damage in brain nerve cells in regions like learning, thinking, and cognitive functions (memory) and ensuing experiences memory loss and speech damage, etc. In this situation, they start to face difficulties in common activities such as trouble to recalling earlier conversations, names/events. Therefore, AD patients are become bed-bound and need help around the clock and can eventually lead to malignancy. The current therapeutic targets of AD include the amelioration of β-amyloid plaque, cholinesterase inhibitors, tau-protein hyper-phosphorylation, biometal dyshomeostasis, and oxidative stress. In this state, pyridine analogues have been accredited as a promising anti-Alzheimer therapeutic leads. Since donepezil and tacrine are two pyridine analogues in the FDA-approved five drugs for the preliminary treatment of AD. Further, pyridine is an important key template for the existence of several natural molecules such as Vitamin B3, β-picoline, quinoline, trigonelline, and coenzymes (e.g., NADP), etc. The Hantzsch synthesis, Emil Knoevenagel process, Aleksei Chichibabin, Bonnemann cyclization, Gattermann–Skita synthesis, and Ciamician–Dennstedt rearrangement are the well-known methods for the synthesis of pyridine analogues. The production of industrial-scale pyridine analogues became easier after the invention of Chichiban synthesis by Russian chemist “Aleksei Chichibabin” through inexpensive staring materials and a more efficient route that is still practiced. Thus, it expands the importance of pyridine analogues for the treatment of AD and hence further studies are recommended for the development of potent anti-Alzheimer drugs. Therefore, the present chapter describes the role of pyridine analogues and their recent developments in the management of multisyndrome AD." @default.
• W4297904506 created "2022-10-01" @default.
• W4297904506 creator A5022447444 @default.
• W4297904506 creator A5024991865 @default.
• W4297904506 creator A5029334364 @default.
• W4297904506 date "2023-01-01" @default.
• W4297904506 modified "2023-09-24" @default.
• W4297904506 title "Recent developments in the synthesis of pyridine analogues as a potent anti-Alzheimer's therapeutic leads" @default.
• W4297904506 cites W1269785928 @default.
• W4297904506 cites W1568323816 @default.
• W4297904506 cites W1606587171 @default.
• W4297904506 cites W1782392325 @default.
• W4297904506 cites W1804425206 @default.
• W4297904506 cites W1927021417 @default.
• W4297904506 cites W1969218941 @default.
• W4297904506 cites W1973476155 @default.
• W4297904506 cites W1975335919 @default.
• W4297904506 cites W2003932771 @default.
• W4297904506 cites W2005009524 @default.
• W4297904506 cites W2006829255 @default.
• W4297904506 cites W2008427917 @default.
• W4297904506 cites W2012034323 @default.
• W4297904506 cites W2017637001 @default.
• W4297904506 cites W2018252229 @default.
• W4297904506 cites W2018372149 @default.
• W4297904506 cites W2020036850 @default.
• W4297904506 cites W2021720965 @default.
• W4297904506 cites W2026275059 @default.
• W4297904506 cites W2029305163 @default.
• W4297904506 cites W2038212451 @default.
• W4297904506 cites W2039295349 @default.
• W4297904506 cites W2043679483 @default.
• W4297904506 cites W2049084706 @default.
• W4297904506 cites W2049334534 @default.
• W4297904506 cites W2069893872 @default.
• W4297904506 cites W2070075494 @default.
• W4297904506 cites W2075606691 @default.
• W4297904506 cites W2076527782 @default.
• W4297904506 cites W2076834193 @default.
• W4297904506 cites W2077812845 @default.
• W4297904506 cites W2089795977 @default.
• W4297904506 cites W2097802864 @default.
• W4297904506 cites W2099853010 @default.
• W4297904506 cites W2108335346 @default.
• W4297904506 cites W2109785891 @default.
• W4297904506 cites W2111537995 @default.
• W4297904506 cites W2112370759 @default.
• W4297904506 cites W2114163624 @default.
• W4297904506 cites W2125757707 @default.
• W4297904506 cites W2128779293 @default.
• W4297904506 cites W2131760568 @default.
• W4297904506 cites W2160250661 @default.
• W4297904506 cites W2169114319 @default.
• W4297904506 cites W2177916499 @default.
• W4297904506 cites W2229686330 @default.
• W4297904506 cites W2316335610 @default.
• W4297904506 cites W2320190638 @default.
• W4297904506 cites W2325995854 @default.
• W4297904506 cites W2345936988 @default.
• W4297904506 cites W2358666620 @default.
• W4297904506 cites W2417284309 @default.
• W4297904506 cites W2419225477 @default.
• W4297904506 cites W2491033299 @default.
• W4297904506 cites W2501352000 @default.
• W4297904506 cites W2526771485 @default.
• W4297904506 cites W2542856291 @default.
• W4297904506 cites W2555174045 @default.
• W4297904506 cites W2559903762 @default.
• W4297904506 cites W2564975307 @default.
• W4297904506 cites W2576150045 @default.
• W4297904506 cites W2613627685 @default.
• W4297904506 cites W2737900099 @default.
• W4297904506 cites W2745394363 @default.
• W4297904506 cites W2748707905 @default.
• W4297904506 cites W2749929717 @default.
• W4297904506 cites W2765880336 @default.
• W4297904506 cites W2770006138 @default.
• W4297904506 cites W2775741251 @default.
• W4297904506 cites W2790798430 @default.
• W4297904506 cites W2791156676 @default.
• W4297904506 cites W2796290277 @default.
• W4297904506 cites W2796417218 @default.
• W4297904506 cites W2804952889 @default.
• W4297904506 cites W2884922442 @default.
• W4297904506 cites W2888262269 @default.
• W4297904506 cites W2888587621 @default.
• W4297904506 cites W2891147283 @default.
• W4297904506 cites W2903800102 @default.
• W4297904506 cites W2904083344 @default.
• W4297904506 cites W2904577036 @default.
• W4297904506 cites W2912487784 @default.
• W4297904506 cites W2913459712 @default.
• W4297904506 cites W2918272868 @default.
• W4297904506 cites W2942400557 @default.
• W4297904506 cites W2945784107 @default.
• W4297904506 cites W2945978249 @default.
• W4297904506 cites W2947929064 @default.
• W4297904506 cites W2950294489 @default.

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