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- W4297909293 abstract "The orexigenic hormone ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), have been extensively studied in the last two decades, revealing that ghrelin signaling has important implications in health and disease. Metabolic diseases, such as obesity and diabetes, are often accompanied by low-grade chronic inflammation, that has been coined as “meta-inflammation.” Immune cells are key cellular mediators of meta-inflammation, controlling both initiation and resolution of inflammation. Immune cells exhibit dynamic changes in cellular characteristics and functional output in response to the stimuli/insults from their surrounding microenvironment. Emerging evidence shows that ghrelin has an important effect on inflammation, in addition to its well-known effects on metabolism. However, the cellular/molecular mechanism of ghrelin signaling in immunity is largely unknown because the knowledge in regard to the expression and function of GHS-R in immune cells is currently sparse. In this review, we have accumulated the recent findings related to the expression and functions of GHS-R in various immune cells under different physiological and pathological states. This review aims to inspire further investigation of the immunological roles of ghrelin signaling and advance the therapeutic applications of ghrelin signaling in meta-inflammation." @default.
- W4297909293 created "2022-10-01" @default.
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- W4297909293 creator A5089863265 @default.
- W4297909293 date "2022-09-23" @default.
- W4297909293 modified "2023-09-29" @default.
- W4297909293 title "The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective" @default.
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- W4297909293 doi "https://doi.org/10.1177/15353702221121635" @default.
- W4297909293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36151745" @default.