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• W4297918254 abstract "The purpose of the study was to assess the validity of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and of pulmonary comorbidity prior to HCT in terms of predicting non-relapse mortality (NRM) and overall survival (OS).In this retrospective single-center study of 663 consecutive adult recipients of HCT, we stratified patients into groups by pulmonary comorbidity: low-risk, intermediate-risk, and high-risk. The predictive value of this pulmonary comorbidity score (PCS) was compared to HCT-CI.In univariate analysis, the HCT-CI and the PCS were associated with OS after transplantation when comparing patients in high-risk groups with patients in low-risk groups. Using the PCS, the hazard ratios (HRs) of the 2-year OS in the entire population and in the myeloablative conditioning (MAC) group were 1.98 (p < .001) and 3.27 (p < .001), respectively, whereas the HRs using the HCT-CI were 1.83 (p < .001) and 2.57 (p = .002). The 2-year NRM incidence in the three risk-groups in the entire population was significant using both indexes. In the MAC group, the 2-year NRM was significant using the PCS (p = .003), but not using the HCT-CI (p = .23).Our study suggest that pulmonary function alone is a strong predictor of 2-year OS and NRM after HCT." @default.
• W4297918254 created "2022-10-01" @default.
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• W4297918254 date "2022-10-21" @default.
• W4297918254 modified "2023-10-16" @default.
• W4297918254 title "Pulmonary function is a strong predictor of 2‐year overall survival and non‐relapse mortality after allogenic hematopoietic cell transplantation" @default.
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• W4297918254 doi "https://doi.org/10.1111/ejh.13869" @default.
• W4297918254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36153797" @default.
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