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- W4297923250 abstract "The association between soft-tissue calcification (STC) and uremia has been recognized for more than 100 years,<sup>1</sup>but it is only since the widespread use of regular dialysis and transplantation that this has become an important problem.<sup>2</sup> Virchow<sup>1</sup>surmised that calcium salts dissolved from bone were carried in the blood and deposited at some distant site to form calcium metastases, a process analogous to the dissemination of cells from a primary neoplasm. In a review of 88 patients,<sup></sup>the underlying cause of metastatic calcification was nonmetabolic bone disease in 35, uremia in 23, primary hyperparathyroidism in 21, and vitamin D intoxication in 9. The lesions typically occur in the kidneys, stomach, lungs, and the left side of the heart, supposedly because of relative local alkalinity.<sup>4</sup>The essential feature of metastatic calcification is its occurrence in previously normal tissue exposed to an abnormal chemical environment, in contrast to dystrophic calcification which occurs in" @default.
- W4297923250 created "2022-10-01" @default.
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- W4297923250 date "1969-11-01" @default.
- W4297923250 modified "2023-10-10" @default.
- W4297923250 title "Soft-Tissue Calcification in Uremia" @default.
- W4297923250 doi "https://doi.org/10.1001/archinte.1969.00300210026004" @default.
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