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• W4297924434 abstract "La quinasa ligada a integrina (ILK) endotelial controla la producción del óxido nítrico, modulando señales de transducción al interior celular. La disminución de ILK endotelial se ha relacionado con la calcificación valvular. Analizamos la asociación de la ILK con la calcificación de la válvula aórtica. Estudio observacional, unicéntrico y prospectivo. Recogimos tejido valvular aórtico de pacientes intervenidos de estenosis aórtica, y controles de válvulas no calcificadas. Cuantificamos los niveles de ILK endotelial empleando técnicas de análisis molecular, así como marcadores de crecimiento óseo (BMP2 y RUNX2). Para el control de factores de confusión empleamos regresión logística múltiple por pasos, introduciendo parámetros relacionados con la aterosclerosis y calcificación valvular (edad, DM, HTA, insuficiencia renal). Obtuvimos muestras de 75 pacientes y 28 controles. El 69,9% eran varones, la edad media fue de 67 años (DE 9,59 años). Los niveles de ILK fueron significativamente más bajos en válvulas patológicas que en controles (0,96 vs. 0,76; p < 0,001). Existió correlación lineal negativa significativa entre la ILK y la calcificación valvular (coeficiente de Pearson = −0,35; p = 0,002). En el modelo multivariante, ILK presentó una asociación significativa con la calcificación valvular (OR 0,068; p < 0,001), así como la DM (OR 11,80; p = 0,03). Observamos un aumento de marcadores de crecimiento óseo según avanzaba la calcificación, con correlación inversa significativa de ILK y BMP2 (R = −0,417; p < 0,001) y RUNX2 (R = −0,587; p < 0,001). La disminución de la expresión endotelial de ILK puede influir en la calcificación de la válvula aórtica, marcando el inicio del proceso de transdiferenciación del endotelio valvular a tejido con capacidad osteogénica. The endothelial integrin-linked kinase (ILK) controls the production of nitric oxide, modulating transduction signals of mechanical stress in the cell. Decreased endothelial ILK has been related to valve calcification. We analyzed the association of ILK expression with aortic valve calcification. Observational, single-center and prospective study. Aortic valve tissue samples were obtained from patients whit aortic stenosis, and controls for non-calcified aortic valves. Endothelial ILK levels were quantified using molecular analysis techniques, as well as bone growth markers (BMP2 and RUNX2). Stepwise multiple logistic regression was used to control for confounding factors, introducing clinical parameters related to atherosclerosis and valve calcification (age, DM, HBP, kidney failure). Samples from 75 patients whit aortic stenosis, and 28 controls were obtained. A percentage of 69.9 were men, mean age 67 years (SD 9.59 years). ILK levels were significantly lower in diseased valves than in controls (0.96 vs. 0.76; P < .001). There was a significant negative linear correlation between ILK and degree of valve calcification (Pearson linear correlation coefficient = −0.35; P = .002).In the multivariate model, ILK was significantly associated with valve calcification (OR adjusted 0.068; P < .001), as well as DM (OR 11.80; P = .03). In addition, an increase in bone growth markers was observed as calcification progressed, with a significant inverse correlation between ILK and BMP2 (R = −0.417; P < .001) and RUNX2 (R = −0.587; P < .001). The decrease in the endothelial expression of ILK may influence the calcification of the aortic valve, marking the beginning of the process of transdifferentiation of the valvular endothelium to tissue with osteogenic capacity." @default.
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• W4297924434 date "2023-01-01" @default.
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• W4297924434 title "Niveles de quinasa ligada a la integrina endotelial y calcificación valvular: estudio molecular de la calcificación en la estenosis valvular aórtica" @default.
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• W4297924434 doi "https://doi.org/10.1016/j.circv.2022.07.002" @default.
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