FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297924596> ?p ?o ?g. }

• W4297924596 endingPage "950" @default.
• W4297924596 startingPage "943" @default.
• W4297924596 abstract "Objectives Exposure of Caco-2 cells to indometacin can be a useful model to assess some of the cytotoxic events that appear to underlie the gastrointestinal lesions associated with the use of this anti-inflammatory agent. Using such a cellular model, we addressed here the cytoprotective potential of a recently standardized apple peel polyphenol extract, APPE. Methods We firstly characterized APPE in terms of its free radical scavenging and antioxidant properties, and subsequently investigated its potential to protect Caco-2 cells against the deleterious effects of indometacin on cellular oxidative status (redox state, malondialdehyde, glutathione (GSH) and oxidized glutathione (GSSG) levels), mitochondrial function (ATP and mitochondrial membrane potential) and cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction and lactate dehydrogenase (LDH) leakage). For comparative purposes, the free radical scavenging properties and reducing capacity of quercetin, epicatechin and rutin were also estimated. Key findings In the absence of APPE, indometacin induced mitochondrial perturbations (reducing ATP and the mitochondrial membrane potential), enhanced the oxidative status (decreasing the GSH/GSSG ratio and increasing dichlorofluorescein oxidation and malondialdehyde) and lowered the cell viability (decreasing MTT reduction and increasing LDH leakage). APPE, whether pre-added or co-incubated with indometacin, concentration-dependently prevented these mitochondrial, oxidative and cell viability alterations. Prompted by the recently recognized ability of indometacin to enhance the mitochondrial formation of reactive oxygen species, APPE was also characterized in terms of its free radical-scavenging capacity. APPE was found to actively scavenge O2·-, HO· and peroxyl radicals. Such free radical-scavenging activity of APPE suggests that its ability to protect mitochondria and prevent the oxidative and lytic damage induced by indometacin arises from its potent antioxidant capacity. Conclusions In Caco-2 cells APPE prevented mitochondrial oxidative and cell viability alterations induced by indometacin possibly through its ability to scavenge reactive oxygen species. These findings are of interest in view of the high prevalence of gastrointestinal side-effects associated with the use of conventional anti-inflammatory agents." @default.
• W4297924596 created "2022-10-01" @default.
• W4297924596 creator A5028064400 @default.
• W4297924596 creator A5030945420 @default.
• W4297924596 creator A5034742281 @default.
• W4297924596 date "2010-06-29" @default.
• W4297924596 modified "2023-10-16" @default.
• W4297924596 title "Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells" @default.
• W4297924596 cites W1497420961 @default.
• W4297924596 cites W1993314624 @default.
• W4297924596 cites W1998183843 @default.
• W4297924596 cites W1998874387 @default.
• W4297924596 cites W2013629449 @default.
• W4297924596 cites W2017005494 @default.
• W4297924596 cites W2019127050 @default.
• W4297924596 cites W2020607118 @default.
• W4297924596 cites W2024121244 @default.
• W4297924596 cites W2026132332 @default.
• W4297924596 cites W2034008612 @default.
• W4297924596 cites W2040004303 @default.
• W4297924596 cites W2040040765 @default.
• W4297924596 cites W2043689968 @default.
• W4297924596 cites W2059285611 @default.
• W4297924596 cites W2063579233 @default.
• W4297924596 cites W2070287417 @default.
• W4297924596 cites W2072259978 @default.
• W4297924596 cites W2078762023 @default.
• W4297924596 cites W2084667605 @default.
• W4297924596 cites W2086694943 @default.
• W4297924596 cites W2086766543 @default.
• W4297924596 cites W2087661881 @default.
• W4297924596 cites W2108577277 @default.
• W4297924596 cites W2134133831 @default.
• W4297924596 cites W2140359867 @default.
• W4297924596 cites W2140803540 @default.
• W4297924596 cites W2152351077 @default.
• W4297924596 cites W2165292984 @default.
• W4297924596 doi "https://doi.org/10.1211/jpp.62.07.0017" @default.
• W4297924596 hasPublicationYear "2010" @default.
• W4297924596 type Work @default.
• W4297924596 citedByCount "37" @default.
• W4297924596 countsByYear W42979245962012 @default.
• W4297924596 countsByYear W42979245962013 @default.
• W4297924596 countsByYear W42979245962014 @default.
• W4297924596 countsByYear W42979245962015 @default.
• W4297924596 countsByYear W42979245962016 @default.
• W4297924596 countsByYear W42979245962017 @default.
• W4297924596 countsByYear W42979245962018 @default.
• W4297924596 countsByYear W42979245962019 @default.
• W4297924596 countsByYear W42979245962020 @default.
• W4297924596 countsByYear W42979245962021 @default.
• W4297924596 countsByYear W42979245962022 @default.
• W4297924596 countsByYear W42979245962023 @default.
• W4297924596 crossrefType "journal-article" @default.
• W4297924596 hasAuthorship W4297924596A5028064400 @default.
• W4297924596 hasAuthorship W4297924596A5030945420 @default.
• W4297924596 hasAuthorship W4297924596A5034742281 @default.
• W4297924596 hasConcept C181199279 @default.
• W4297924596 hasConcept C185592680 @default.
• W4297924596 hasConcept C190283241 @default.
• W4297924596 hasConcept C2776151105 @default.
• W4297924596 hasConcept C2776980637 @default.
• W4297924596 hasConcept C2778004101 @default.
• W4297924596 hasConcept C2778401633 @default.
• W4297924596 hasConcept C2779296319 @default.
• W4297924596 hasConcept C28859421 @default.
• W4297924596 hasConcept C2909020919 @default.
• W4297924596 hasConcept C48349386 @default.
• W4297924596 hasConcept C53227056 @default.
• W4297924596 hasConcept C538909803 @default.
• W4297924596 hasConcept C55493867 @default.
• W4297924596 hasConcept C57600042 @default.
• W4297924596 hasConcept C86803240 @default.
• W4297924596 hasConcept C98274493 @default.
• W4297924596 hasConceptScore W4297924596C181199279 @default.
• W4297924596 hasConceptScore W4297924596C185592680 @default.
• W4297924596 hasConceptScore W4297924596C190283241 @default.
• W4297924596 hasConceptScore W4297924596C2776151105 @default.
• W4297924596 hasConceptScore W4297924596C2776980637 @default.
• W4297924596 hasConceptScore W4297924596C2778004101 @default.
• W4297924596 hasConceptScore W4297924596C2778401633 @default.
• W4297924596 hasConceptScore W4297924596C2779296319 @default.
• W4297924596 hasConceptScore W4297924596C28859421 @default.
• W4297924596 hasConceptScore W4297924596C2909020919 @default.
• W4297924596 hasConceptScore W4297924596C48349386 @default.
• W4297924596 hasConceptScore W4297924596C53227056 @default.
• W4297924596 hasConceptScore W4297924596C538909803 @default.
• W4297924596 hasConceptScore W4297924596C55493867 @default.
• W4297924596 hasConceptScore W4297924596C57600042 @default.
• W4297924596 hasConceptScore W4297924596C86803240 @default.
• W4297924596 hasConceptScore W4297924596C98274493 @default.
• W4297924596 hasIssue "7" @default.
• W4297924596 hasLocation W42979245961 @default.
• W4297924596 hasOpenAccess W4297924596 @default.
• W4297924596 hasPrimaryLocation W42979245961 @default.
• W4297924596 hasRelatedWork W125774832 @default.
• W4297924596 hasRelatedWork W1579032403 @default.
• W4297924596 hasRelatedWork W188720285 @default.

• next