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- W4297944034 abstract "Current advances in the study of hypertrophic osteoarthropathy are discussed. An update of the classification of hypertrophic osteoarthropathy is given in which the POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is included among the associated diseases. Cyanotic heart disease is the internal illness most closely linked to hypertrophic osteoarthropathy. The bony alterations at the distal phalanxes and on the periosteum of the tubular bones leave a characteristic and indelible mark that can be diagnosed centuries after the death of the individual. Current thinking suggests that localized activation of endothelial cells by an abnormal platelet population, with the ensuing release of fibroblast growth factors, plays a central role in the pathogenesis of the acropachy. Antiphospholipid syndrome may be a feature of cardiogenic hypertrophic osteoarthropathy. Unraveling the mechanisms of hypertrophic osteoarthropathy may help in understanding the pathogenesis of the associated diseases." @default.
- W4297944034 created "2022-10-01" @default.
- W4297944034 creator A5005737443 @default.
- W4297944034 date "2012-01-20" @default.
- W4297944034 modified "2023-10-16" @default.
- W4297944034 title "Hypertrophic Osteoarthropathy" @default.
- W4297944034 cites W2049123735 @default.
- W4297944034 doi "https://doi.org/10.1007/springerreference_109560" @default.
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- W4297944034 hasPublicationYear "2012" @default.
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