FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297982535> ?p ?o ?g. }

• W4297982535 endingPage "1396" @default.
• W4297982535 startingPage "1396" @default.
• W4297982535 abstract "Caenorhabditis elegans (C. elegans) is a nematode present worldwide. The worm shows homology to mammalian systems and expresses approximately 40% of human disease-related genes. Since Dr. Sydney Brenner first proposed C. elegans as an advantageous experimental worm-model system for genetic approaches, increasing numbers of studies using C. elegans as a tool to investigate topics in several fields of biochemistry, neuroscience, pharmacology, and toxicology have been performed. In this regard, C. elegans has been used to characterize the molecular mechanisms and affected pathways caused by metals that lead to neurotoxicity, as well as the pathophysiological interrelationship between metal exposure and ongoing neurodegenerative disorders. Several toxic metals, such as lead, cadmium, and mercury, are recognized as important environmental contaminants, and their exposure is associated with toxic effects on the human body. Essential elements that are required to maintain cellular homeostasis and normal physiological functions may also be toxic when accumulated at higher concentrations. For instance, manganese (Mn) is a trace essential element that participates in numerous biological processes, such as enzymatic activities, energy metabolism, and maintenance of cell functions. However, Mn overexposure is associated with behavioral changes in C. elegans, which are consistent with the dopaminergic system being the primary target of Mn neurotoxicity. Caenorhabditis elegans has been shown to be an important tool that allows for studies on neuron morphology using fluorescent transgenic worms. Moreover, behavioral tests may be conducted using worms, and neurotransmitter determination and related gene expression are likely to change after Mn exposure. Likewise, mutant worms may be used to study molecular mechanisms in Mn toxicity, as well as the expression of proteins responsible for the biosynthesis, transport, storage, and uptake of dopamine. Furthermore, this review highlights some advantages and limitations of using the experimental model of C. elegans and provides guidance for potential future applications of this model in studies directed toward assessing for Mn neurotoxicity and related mechanisms." @default.
• W4297982535 created "2022-10-01" @default.
• W4297982535 creator A5002802326 @default.
• W4297982535 creator A5003074350 @default.
• W4297982535 creator A5021254405 @default.
• W4297982535 creator A5027976892 @default.
• W4297982535 creator A5034245945 @default.
• W4297982535 creator A5035503566 @default.
• W4297982535 creator A5074376954 @default.
• W4297982535 creator A5077576838 @default.
• W4297982535 creator A5077849438 @default.
• W4297982535 date "2022-09-29" @default.
• W4297982535 modified "2023-09-30" @default.
• W4297982535 title "Caenorhabditis elegans as a Model to Study Manganese-Induced Neurotoxicity" @default.
• W4297982535 cites W1501366749 @default.
• W4297982535 cites W150246076 @default.
• W4297982535 cites W1525805237 @default.
• W4297982535 cites W1571414277 @default.
• W4297982535 cites W1853341716 @default.
• W4297982535 cites W1924594419 @default.
• W4297982535 cites W1944127002 @default.
• W4297982535 cites W1968971029 @default.
• W4297982535 cites W1969508296 @default.
• W4297982535 cites W1970826466 @default.
• W4297982535 cites W1971970412 @default.
• W4297982535 cites W1974183873 @default.
• W4297982535 cites W1979562512 @default.
• W4297982535 cites W1982141010 @default.
• W4297982535 cites W1983814182 @default.
• W4297982535 cites W1989122526 @default.
• W4297982535 cites W1990481377 @default.
• W4297982535 cites W1993860278 @default.
• W4297982535 cites W1996113127 @default.
• W4297982535 cites W1996761102 @default.
• W4297982535 cites W1998271947 @default.
• W4297982535 cites W1999801552 @default.
• W4297982535 cites W2000942593 @default.
• W4297982535 cites W2001003591 @default.
• W4297982535 cites W2001920462 @default.
• W4297982535 cites W2002837323 @default.
• W4297982535 cites W2005002747 @default.
• W4297982535 cites W2009036259 @default.
• W4297982535 cites W2009688381 @default.
• W4297982535 cites W2012222058 @default.
• W4297982535 cites W2013476094 @default.
• W4297982535 cites W2023018514 @default.
• W4297982535 cites W2024562943 @default.
• W4297982535 cites W2031305146 @default.
• W4297982535 cites W2031313941 @default.
• W4297982535 cites W2031682729 @default.
• W4297982535 cites W2032579724 @default.
• W4297982535 cites W2033293431 @default.
• W4297982535 cites W2036284461 @default.
• W4297982535 cites W2038341793 @default.
• W4297982535 cites W2039142811 @default.
• W4297982535 cites W2039527951 @default.
• W4297982535 cites W2039936432 @default.
• W4297982535 cites W2040708668 @default.
• W4297982535 cites W2041348758 @default.
• W4297982535 cites W2046351755 @default.
• W4297982535 cites W2047495081 @default.
• W4297982535 cites W2047923314 @default.
• W4297982535 cites W2048599012 @default.
• W4297982535 cites W2055956984 @default.
• W4297982535 cites W2060947179 @default.
• W4297982535 cites W2061995199 @default.
• W4297982535 cites W2065566230 @default.
• W4297982535 cites W2066621059 @default.
• W4297982535 cites W2066681114 @default.
• W4297982535 cites W2067147530 @default.
• W4297982535 cites W2067354437 @default.
• W4297982535 cites W2070296921 @default.
• W4297982535 cites W2071786082 @default.
• W4297982535 cites W2073909766 @default.
• W4297982535 cites W2079441999 @default.
• W4297982535 cites W2081017165 @default.
• W4297982535 cites W2081592335 @default.
• W4297982535 cites W2081671164 @default.
• W4297982535 cites W2082642514 @default.
• W4297982535 cites W2084771848 @default.
• W4297982535 cites W2091840771 @default.
• W4297982535 cites W2092111364 @default.
• W4297982535 cites W2106562217 @default.
• W4297982535 cites W2108024591 @default.
• W4297982535 cites W2108886647 @default.
• W4297982535 cites W2117821054 @default.
• W4297982535 cites W2119620429 @default.
• W4297982535 cites W2120372333 @default.
• W4297982535 cites W2120802226 @default.
• W4297982535 cites W2132326719 @default.
• W4297982535 cites W2138421704 @default.
• W4297982535 cites W2138731844 @default.
• W4297982535 cites W2140305655 @default.
• W4297982535 cites W2146688490 @default.
• W4297982535 cites W2157657212 @default.
• W4297982535 cites W2158474392 @default.
• W4297982535 cites W2160938187 @default.
• W4297982535 cites W2163364014 @default.

• next