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• W4297983532 endingPage "15671" @default.
• W4297983532 startingPage "15603" @default.
• W4297983532 abstract "Glycoconjugates are major constituents of mammalian cells that are formed via covalent conjugation of carbohydrates to other biomolecules like proteins and lipids and often expressed on the cell surfaces. Among the three major classes of glycoconjugates, proteoglycans and glycoproteins contain glycans linked to the protein backbone via amino acid residues such as Asn for N-linked glycans and Ser/Thr for O-linked glycans. In glycolipids, glycans are linked to a lipid component such as glycerol, polyisoprenyl pyrophosphate, fatty acid ester, or sphingolipid. Recently, glycoconjugates have become better structurally defined and biosynthetically understood, especially those associated with human diseases, and are accessible to new drug, diagnostic, and therapeutic developments. This review describes the status and new advances in the biological study and therapeutic applications of natural and synthetic glycoconjugates, including proteoglycans, glycoproteins, and glycolipids. The scope, limitations, and novel methodologies in the synthesis and clinical development of glycoconjugates including vaccines, glyco-remodeled antibodies, glycan-based adjuvants, glycan-specific receptor-mediated drug delivery platforms, etc., and their future prospectus are discussed." @default.
• W4297983532 created "2022-10-01" @default.
• W4297983532 creator A5058995042 @default.
• W4297983532 creator A5070129105 @default.
• W4297983532 creator A5083272386 @default.
• W4297983532 date "2022-09-29" @default.
• W4297983532 modified "2023-09-30" @default.
• W4297983532 title "Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments" @default.
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