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• W4297983818 abstract "Abstract Backgrround The randomized trials include ACOSOG Z0011 and IBCSG 23 − 01 had found that, the survival rates were not different in patients with cT1/2N0 and 1–2 sentinel lymph node (SLN) positive, macro/micro metastases who underwent breast-conserving therapy and micrometastases who underwent total mastectomy (TM), when axillary lymph node dissection (ALND) was omitted. However, for patients with cT1/2N0 and 1–2 SLN macrometastases who underwent TM, there was no published clinical research evidence whether ALND can be exempted. This study aimed to investigate the risk factors of non-sentinel lymph node (nSLN) metastasis in breast cancer patients with 1–2 SLN macrometastases undergoing TM. Methods The clinicopathological data of 1491 breast cancer patients underwent TM and SLNB from January 2017 to February 2022 were retrospectively analyzed. Univariate and multivariate analyses were performed to analyze the risk factors for nSLN metastasis. Results A total of 273 patients with 1–2 SLN macrometastases underwent TM were enrolled. Postoperative pathological data showed that 35.2% patients had nSLN metastasis. The results of multivariate analysis indicated that tumor size (TS) (P = 0.002; OR: 1.051; 95% CI: 1.019–1.084) and ratio of SLN macrometastases (P = 0.0001; OR: 12.597: 95% CI: 4.302–36.890) were the independent risk factors for nSLN metastasis in breast cancer with 1–2 SLN macrometastases underwent TM. The ROC curve analysis suggested that when TS ≤ 22mm and ratio of SLN macrometastases ≤ 0.33, the incidence of nSLN metastasis could be reduced to 17.1%. Conclusions The breast cancer patients with cT1/2N0 stage, undergoing TM and 1–2 SLN macrometastases, when the TS ≤ 22mm and macrometastatic SLN does not exceed 1/3 of the total number of detected SLN, the incidence of nSLN metastasis is significantly reduced, and whether ALND can be exempted deserves further exploration." @default.
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• W4297983818 date "2022-09-29" @default.
• W4297983818 modified "2023-10-18" @default.
• W4297983818 title "Risk factors of non-sentinel lymph node metastasis in breast cancer with 1–2 sentinel lymph node micrometastases: a case control study" @default.
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• W4297983818 doi "https://doi.org/10.21203/rs.3.rs-2091343/v1" @default.
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