FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297984090> ?p ?o ?g. }

• W4297984090 endingPage "471" @default.
• W4297984090 startingPage "466" @default.
• W4297984090 abstract "Psychedelic compounds such as 3,4-methylenedioxymethamphetamine (MDMA) have attracted increasing interest in recent years because of their therapeutic potential in psychiatric disorders. To understand the acute effects of psychedelic drugs in vivo, blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) has been widely used. In particular, fMRI studies have suggested that MDMA leads to inhibition of brain activity, challenging previous hypotheses indicating mainly excitatory effects based, among others, on increased metabolism shown by 18F-FDG functional PET (fPET). However, interpretation of hemodynamic changes induced by psychedelics is difficult because of their potent vascular effects. Methods: We aimed to delineate the acute effects of MDMA using simultaneous PET/fMRI in rats. For this purpose, hemodynamic changes measured by BOLD fMRI were related to alterations in glucose utilization and serotonin transporter (SERT) occupancy using 18F-FDG fPET/fMRI and 11C-DASB PET/fMRI. Results: We show that MDMA induces localized increases in glucose metabolism in limbic projection areas involved in emotional processing. The increased glucose metabolism was accompanied by global cerebral and extracerebral hemodynamic decreases. We further demonstrated a strong correlation between SERT occupancies and regional BOLD reductions after acute MDMA administration. Conclusion: Our data indicate that hemodynamic decreases after acute MDMA administration are of a nonneuronal nature and initiate peripherally. Within the brain, MDMA triggers neuronal activation in limbic projection areas, whereas increased serotonin levels induced by SERT blockage cause neurovascular uncoupling through direct vascular effects. Correct understanding of the in vivo mechanism of MDMA not only supports ongoing research but also warrants a reassessment of previous studies on neuronal effects of psychedelics relying on neurovascular coupling and recommends 18F-FDG fPET as a potentially more robust measure for pharmacologic research." @default.
• W4297984090 created "2022-10-01" @default.
• W4297984090 creator A5004578739 @default.
• W4297984090 creator A5018788118 @default.
• W4297984090 creator A5019683699 @default.
• W4297984090 creator A5020683761 @default.
• W4297984090 creator A5021151911 @default.
• W4297984090 creator A5030229988 @default.
• W4297984090 creator A5037569140 @default.
• W4297984090 creator A5054942187 @default.
• W4297984090 creator A5077765248 @default.
• W4297984090 date "2022-09-29" @default.
• W4297984090 modified "2023-10-14" @default.
• W4297984090 title "Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine" @default.
• W4297984090 cites W12984134 @default.
• W4297984090 cites W1963722081 @default.
• W4297984090 cites W1970995383 @default.
• W4297984090 cites W1975605971 @default.
• W4297984090 cites W1980882035 @default.
• W4297984090 cites W1983947475 @default.
• W4297984090 cites W1989097006 @default.
• W4297984090 cites W1990926259 @default.
• W4297984090 cites W1991760461 @default.
• W4297984090 cites W1995838863 @default.
• W4297984090 cites W2011320995 @default.
• W4297984090 cites W2013498451 @default.
• W4297984090 cites W2014643576 @default.
• W4297984090 cites W2015641758 @default.
• W4297984090 cites W2026832357 @default.
• W4297984090 cites W2037364400 @default.
• W4297984090 cites W2042422091 @default.
• W4297984090 cites W2045365443 @default.
• W4297984090 cites W2048509938 @default.
• W4297984090 cites W2050297923 @default.
• W4297984090 cites W2058784273 @default.
• W4297984090 cites W2069625646 @default.
• W4297984090 cites W2080693003 @default.
• W4297984090 cites W2087940450 @default.
• W4297984090 cites W2097563002 @default.
• W4297984090 cites W2106193331 @default.
• W4297984090 cites W2116658855 @default.
• W4297984090 cites W2124714506 @default.
• W4297984090 cites W2130199588 @default.
• W4297984090 cites W2135430763 @default.
• W4297984090 cites W2135538008 @default.
• W4297984090 cites W2140933156 @default.
• W4297984090 cites W2151786648 @default.
• W4297984090 cites W2154105276 @default.
• W4297984090 cites W2166045982 @default.
• W4297984090 cites W2226432962 @default.
• W4297984090 cites W2550622086 @default.
• W4297984090 cites W2762061855 @default.
• W4297984090 cites W2810491645 @default.
• W4297984090 cites W2883210621 @default.
• W4297984090 cites W2886742813 @default.
• W4297984090 cites W2930497278 @default.
• W4297984090 cites W2936775109 @default.
• W4297984090 cites W3005995107 @default.
• W4297984090 cites W3047587412 @default.
• W4297984090 cites W3096897894 @default.
• W4297984090 cites W3155327247 @default.
• W4297984090 cites W3160990818 @default.
• W4297984090 cites W4213225776 @default.
• W4297984090 doi "https://doi.org/10.2967/jnumed.122.264391" @default.
• W4297984090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36175138" @default.
• W4297984090 hasPublicationYear "2022" @default.
• W4297984090 type Work @default.
• W4297984090 citedByCount "2" @default.
• W4297984090 countsByYear W42979840902023 @default.
• W4297984090 crossrefType "journal-article" @default.
• W4297984090 hasAuthorship W4297984090A5004578739 @default.
• W4297984090 hasAuthorship W4297984090A5018788118 @default.
• W4297984090 hasAuthorship W4297984090A5019683699 @default.
• W4297984090 hasAuthorship W4297984090A5020683761 @default.
• W4297984090 hasAuthorship W4297984090A5021151911 @default.
• W4297984090 hasAuthorship W4297984090A5030229988 @default.
• W4297984090 hasAuthorship W4297984090A5037569140 @default.
• W4297984090 hasAuthorship W4297984090A5054942187 @default.
• W4297984090 hasAuthorship W4297984090A5077765248 @default.
• W4297984090 hasBestOaLocation W42979840901 @default.
• W4297984090 hasConcept C124315065 @default.
• W4297984090 hasConcept C126322002 @default.
• W4297984090 hasConcept C15744967 @default.
• W4297984090 hasConcept C169760540 @default.
• W4297984090 hasConcept C170493617 @default.
• W4297984090 hasConcept C178853913 @default.
• W4297984090 hasConcept C26170363 @default.
• W4297984090 hasConcept C2775864247 @default.
• W4297984090 hasConcept C2777953023 @default.
• W4297984090 hasConcept C2778897192 @default.
• W4297984090 hasConcept C2780876324 @default.
• W4297984090 hasConcept C42219234 @default.
• W4297984090 hasConcept C71924100 @default.
• W4297984090 hasConcept C74254510 @default.
• W4297984090 hasConcept C84393581 @default.
• W4297984090 hasConcept C98274493 @default.
• W4297984090 hasConceptScore W4297984090C124315065 @default.
• W4297984090 hasConceptScore W4297984090C126322002 @default.

• next