Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297988230> ?p ?o ?g. }
- W4297988230 endingPage "6435" @default.
- W4297988230 startingPage "6435" @default.
- W4297988230 abstract "Knoxia roxburghii (Spreng.) M. A. Rau (KR) is a plant clinically used in traditional Chinese medicine (TCM) for the treatment of cancer. The study objectives were to examine the effects of KR extracts, petroleum ether (PET), ethyl acetate (EtoAc), butanol (n-BuOH), and H2O-soluble fractions (HSF) of the 75% EtOH extraction on A549 (non-small cell lung cancer), HepG2 (liver cancer), HeLa (cervical cancer), MCF-7 (breast cancer), and L02 (normal hepatocyte) cells. It was found that HSF exhibited the strongest cytotoxic activity against MCF-7 cells, and was accompanied by reduced mitochondrial transmembrane potential, increased levels of intra-cellular reactive oxygen species (ROS) and activated caspases, and upregulated pro-apoptotic and downregulated anti-apoptotic proteins. LC-MS analysis further showed that HSF primarily consisted of calycosin, aloe emodin, rein, maackiain, asperuloside, orientin, vicenin-2, and kaempferide, which have been mostly reported for anti-tumor activity in previous studies. In summary, the current study illustrated the effect, mechanism, and the potential major active components of KR against breast cancer." @default.
- W4297988230 created "2022-10-01" @default.
- W4297988230 creator A5006923447 @default.
- W4297988230 creator A5015932823 @default.
- W4297988230 creator A5016136652 @default.
- W4297988230 creator A5022819161 @default.
- W4297988230 creator A5033684035 @default.
- W4297988230 creator A5053447705 @default.
- W4297988230 creator A5072886386 @default.
- W4297988230 creator A5075299330 @default.
- W4297988230 creator A5076106119 @default.
- W4297988230 creator A5078451463 @default.
- W4297988230 date "2022-09-29" @default.
- W4297988230 modified "2023-09-22" @default.
- W4297988230 title "Extracts of Knoxia roxburghii (Spreng.) M. A. Rau Induce Apoptosis in Human MCF-7 Breast Cancer Cells via Mitochondrial Pathways" @default.
- W4297988230 cites W1903875142 @default.
- W4297988230 cites W1969500799 @default.
- W4297988230 cites W1980157584 @default.
- W4297988230 cites W2033354566 @default.
- W4297988230 cites W2042534036 @default.
- W4297988230 cites W2067197152 @default.
- W4297988230 cites W2069540150 @default.
- W4297988230 cites W2070729508 @default.
- W4297988230 cites W2072719327 @default.
- W4297988230 cites W2094026960 @default.
- W4297988230 cites W2103023937 @default.
- W4297988230 cites W2120260995 @default.
- W4297988230 cites W2153394357 @default.
- W4297988230 cites W2156432545 @default.
- W4297988230 cites W2164620725 @default.
- W4297988230 cites W2279453021 @default.
- W4297988230 cites W2287078744 @default.
- W4297988230 cites W2325008670 @default.
- W4297988230 cites W2326598704 @default.
- W4297988230 cites W2328987043 @default.
- W4297988230 cites W2479501302 @default.
- W4297988230 cites W2490404511 @default.
- W4297988230 cites W2507218553 @default.
- W4297988230 cites W2553938351 @default.
- W4297988230 cites W2579009723 @default.
- W4297988230 cites W2604178846 @default.
- W4297988230 cites W2751016512 @default.
- W4297988230 cites W2763548994 @default.
- W4297988230 cites W2766112735 @default.
- W4297988230 cites W2767870395 @default.
- W4297988230 cites W2782483731 @default.
- W4297988230 cites W2793003211 @default.
- W4297988230 cites W2884452328 @default.
- W4297988230 cites W2888586841 @default.
- W4297988230 cites W2911072892 @default.
- W4297988230 cites W2920207301 @default.
- W4297988230 cites W2932962868 @default.
- W4297988230 cites W2938055770 @default.
- W4297988230 cites W2948583128 @default.
- W4297988230 cites W2976144753 @default.
- W4297988230 cites W2978324901 @default.
- W4297988230 cites W2980888740 @default.
- W4297988230 cites W2991239420 @default.
- W4297988230 cites W2995204555 @default.
- W4297988230 cites W3013140447 @default.
- W4297988230 cites W3081766100 @default.
- W4297988230 cites W3100409621 @default.
- W4297988230 cites W3137308624 @default.
- W4297988230 cites W3138202210 @default.
- W4297988230 cites W3161653475 @default.
- W4297988230 cites W3181421885 @default.
- W4297988230 cites W3192501127 @default.
- W4297988230 cites W3216513162 @default.
- W4297988230 cites W4200407979 @default.
- W4297988230 cites W4214572413 @default.
- W4297988230 cites W4214896600 @default.
- W4297988230 cites W9749828 @default.
- W4297988230 doi "https://doi.org/10.3390/molecules27196435" @default.
- W4297988230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36234972" @default.
- W4297988230 hasPublicationYear "2022" @default.
- W4297988230 type Work @default.
- W4297988230 citedByCount "2" @default.
- W4297988230 countsByYear W42979882302023 @default.
- W4297988230 crossrefType "journal-article" @default.
- W4297988230 hasAuthorship W4297988230A5006923447 @default.
- W4297988230 hasAuthorship W4297988230A5015932823 @default.
- W4297988230 hasAuthorship W4297988230A5016136652 @default.
- W4297988230 hasAuthorship W4297988230A5022819161 @default.
- W4297988230 hasAuthorship W4297988230A5033684035 @default.
- W4297988230 hasAuthorship W4297988230A5053447705 @default.
- W4297988230 hasAuthorship W4297988230A5072886386 @default.
- W4297988230 hasAuthorship W4297988230A5075299330 @default.
- W4297988230 hasAuthorship W4297988230A5076106119 @default.
- W4297988230 hasAuthorship W4297988230A5078451463 @default.
- W4297988230 hasBestOaLocation W42979882301 @default.
- W4297988230 hasConcept C109541995 @default.
- W4297988230 hasConcept C121608353 @default.
- W4297988230 hasConcept C126322002 @default.
- W4297988230 hasConcept C1491633281 @default.
- W4297988230 hasConcept C153911025 @default.
- W4297988230 hasConcept C185592680 @default.
- W4297988230 hasConcept C190283241 @default.
- W4297988230 hasConcept C2777366897 @default.