Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297989192> ?p ?o ?g. }
- W4297989192 abstract "A theoretical investigation was performed to disclose the transformation mechanism of 8-oxoG•+ to protonated 5-OH-8-oxoG in base pair. The energy profiles for three possible pathways of the events were mapped. It is shown that direct loss of H7 from base paired 8-oxoG•+ is the only energetically favorable pathway to generate neutral radical, 8-oxoG(-H7)• . Further oxidation of 8-oxoG(-H7)• :C to 8-oxoG(-H7)+:C is exothermic. However, the 8-oxoG(-H7)+:C deprotonation from all possible active sites is infeasible, indicating the inaccessible second proton loss and the lack of essential intermediate 2-amino-7,9-dihydropurine-6,8-dione (8-oxoGOX ). This makes 8-oxoG(-H7)+ act as the precursor of hydration leading to the generation of protonated 5-HO-8-oxoG by stepwise fashion in base pair, which would initiate the step down Gh pathway. These results clearly specify the structure-dependent transformation for 8-oxoG•+ and verify the emergence of protonated 5-HO-8-oxoG in base pair." @default.
- W4297989192 created "2022-10-01" @default.
- W4297989192 creator A5014471111 @default.
- W4297989192 creator A5023392683 @default.
- W4297989192 creator A5056628952 @default.
- W4297989192 creator A5058340366 @default.
- W4297989192 creator A5065090843 @default.
- W4297989192 creator A5077958968 @default.
- W4297989192 date "2022-10-27" @default.
- W4297989192 modified "2023-10-17" @default.
- W4297989192 title "An Exploration of the Transformation of the 8‐Oxo‐7,8‐Dihydroguanine Radical Cation to Protonated 2‐Amino‐5‐Hydroxy‐7,9‐Dihydropurine‐6,8‐Dione in a Base Pair" @default.
- W4297989192 cites W1576668315 @default.
- W4297989192 cites W1748328858 @default.
- W4297989192 cites W1968969258 @default.
- W4297989192 cites W1969936088 @default.
- W4297989192 cites W1976706105 @default.
- W4297989192 cites W1978252186 @default.
- W4297989192 cites W1980365138 @default.
- W4297989192 cites W1986647268 @default.
- W4297989192 cites W1986758432 @default.
- W4297989192 cites W1987165826 @default.
- W4297989192 cites W1993995910 @default.
- W4297989192 cites W2001258368 @default.
- W4297989192 cites W2002125632 @default.
- W4297989192 cites W2011215428 @default.
- W4297989192 cites W2018909475 @default.
- W4297989192 cites W2020909889 @default.
- W4297989192 cites W2022140686 @default.
- W4297989192 cites W2024246776 @default.
- W4297989192 cites W2026838497 @default.
- W4297989192 cites W2029257212 @default.
- W4297989192 cites W2035253002 @default.
- W4297989192 cites W2038083805 @default.
- W4297989192 cites W2040530338 @default.
- W4297989192 cites W2041579368 @default.
- W4297989192 cites W2044710231 @default.
- W4297989192 cites W2047001643 @default.
- W4297989192 cites W2051531745 @default.
- W4297989192 cites W2052211560 @default.
- W4297989192 cites W2053861316 @default.
- W4297989192 cites W2058044047 @default.
- W4297989192 cites W2080954815 @default.
- W4297989192 cites W2081225770 @default.
- W4297989192 cites W2083015319 @default.
- W4297989192 cites W2131531043 @default.
- W4297989192 cites W2150697053 @default.
- W4297989192 cites W2152768401 @default.
- W4297989192 cites W2194964178 @default.
- W4297989192 cites W2236951518 @default.
- W4297989192 cites W2312328902 @default.
- W4297989192 cites W2319925337 @default.
- W4297989192 cites W2620560609 @default.
- W4297989192 cites W2756313385 @default.
- W4297989192 cites W2796021451 @default.
- W4297989192 cites W2810084433 @default.
- W4297989192 cites W2900376084 @default.
- W4297989192 cites W2909094642 @default.
- W4297989192 cites W2920143962 @default.
- W4297989192 cites W2967259220 @default.
- W4297989192 cites W3003792454 @default.
- W4297989192 cites W3010628173 @default.
- W4297989192 cites W3014884021 @default.
- W4297989192 cites W3037793508 @default.
- W4297989192 cites W3086151876 @default.
- W4297989192 cites W3157638995 @default.
- W4297989192 cites W3166913560 @default.
- W4297989192 cites W3168800234 @default.
- W4297989192 cites W3199968423 @default.
- W4297989192 cites W4235524474 @default.
- W4297989192 doi "https://doi.org/10.1002/cphc.202200625" @default.
- W4297989192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36175389" @default.
- W4297989192 hasPublicationYear "2022" @default.
- W4297989192 type Work @default.
- W4297989192 citedByCount "1" @default.
- W4297989192 countsByYear W42979891922023 @default.
- W4297989192 crossrefType "journal-article" @default.
- W4297989192 hasAuthorship W4297989192A5014471111 @default.
- W4297989192 hasAuthorship W4297989192A5023392683 @default.
- W4297989192 hasAuthorship W4297989192A5056628952 @default.
- W4297989192 hasAuthorship W4297989192A5058340366 @default.
- W4297989192 hasAuthorship W4297989192A5065090843 @default.
- W4297989192 hasAuthorship W4297989192A5077958968 @default.
- W4297989192 hasConcept C118629725 @default.
- W4297989192 hasConcept C121332964 @default.
- W4297989192 hasConcept C134306372 @default.
- W4297989192 hasConcept C145148216 @default.
- W4297989192 hasConcept C178790620 @default.
- W4297989192 hasConcept C185581394 @default.
- W4297989192 hasConcept C185592680 @default.
- W4297989192 hasConcept C30095370 @default.
- W4297989192 hasConcept C33923547 @default.
- W4297989192 hasConcept C42058472 @default.
- W4297989192 hasConcept C54516573 @default.
- W4297989192 hasConcept C552990157 @default.
- W4297989192 hasConcept C55493867 @default.
- W4297989192 hasConcept C62520636 @default.
- W4297989192 hasConcept C71240020 @default.
- W4297989192 hasConcept C8010536 @default.
- W4297989192 hasConceptScore W4297989192C118629725 @default.
- W4297989192 hasConceptScore W4297989192C121332964 @default.