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- W4297989504 endingPage "120172" @default.
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- W4297989504 abstract "The stickiest natural polysaccharide, levan, plays a role in metalloproteinase activation, which is an important step involved in the healing of injured tissue. However, levan is easily diluted, washed away, and loses adhesion in wet environments, which limits its biomedical applications. Herein, we demonstrate a strategy for fabricating a levan-based adhesive hydrogel for hemostatic and wound healing applications by conjugating catechol to levan. Prepared hydrogels exhibit significantly improved water solubilities, and adhesion strengths to hydrated porcine skin of up to 42.17 ± 0.24 kPa which is more than three-times that of fibrin glue adhesive. The hydrogels also promote rapid blood clotting and significantly faster healing of rat-skin incisions compared to nontreated samples. In addition, levan-catechol exhibited an immune response close to that of the negative control, which is ascribable to its significantly lower endotoxin level compared to native levan. Overall, levan-catechol hydrogels are promising materials for hemostatic and wound healing applications." @default.
- W4297989504 created "2022-10-01" @default.
- W4297989504 creator A5003460383 @default.
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- W4297989504 date "2023-01-01" @default.
- W4297989504 modified "2023-10-11" @default.
- W4297989504 title "A sticky carbohydrate meets a mussel adhesive: Catechol-conjugated levan for hemostatic and wound healing applications" @default.
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- W4297989504 doi "https://doi.org/10.1016/j.carbpol.2022.120172" @default.
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