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- W4297989727 abstract "Abstract The occlusion of dentinal tubules has become a rapid and effective method for treating dentin hypersensitivity. Accurate evaluation of dentin occlusion is critical to illustrate the efficacy of oral care products and to optimize dental therapy in the clinics, which is limited by the conventional two-dimensional (2-D) characterization methods. Here, we demonstrate the visualization of the dentin occlusion via three-dimensional (3-D) characterization using a focused ion beam-scanning electron microscopy (FIB-SEM) tomography. Using the “Slice and View” approach, the material used for occluding dentin tubules is imaged with a very high-resolution voxel (10 nm × 10 nm × 20 nm) from 2-D SEM images and then reconstructed into a 3-D volume, which presents the mode of action of toothpaste for treating dentin hypersensitivity. Meanwhile, quantitative analysis of the depth of occlusion is successfully obtained. This work validates the feasibility of FIB-SEM tomography in the analysis of dentin occlusion within the complicated networks of dentine tubules at the nanoscale, and provides a novel approach to facilitate the research and development of oral care products." @default.
- W4297989727 created "2022-10-01" @default.
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- W4297989727 date "2022-09-29" @default.
- W4297989727 modified "2023-10-18" @default.
- W4297989727 title "Three-Dimensional Visualization of Dentine Occlusion Based on FIB-SEM Tomography" @default.
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- W4297989727 doi "https://doi.org/10.21203/rs.3.rs-2081884/v1" @default.
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