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- W4297991569 abstract "Abstract Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS oligosaccharides bearing systematically varied sulfation structures are available owing to the challenges in synthesizing a large number of HS oligosaccharides. To overcome the obstacles and expedite the synthesis, a divergent approach was designed, where 64 HS tetrasaccharides covering all possible structures of 2‐ O ‐, 6‐ O ‐ and N ‐sulfation with the glucosamine‐glucuronic acid‐glucosamine‐iduronic acid backbone were successfully produced from a single strategically protected tetrasaccharide intermediate. This extensive library helped identify the structural requirements for HS sequences to have strong fibroblast growth factor‐2 binding but a weak affinity for platelet factor‐4. Such a strategy to separate out these two interactions could lead to new HS‐based potential therapeutics without the dangerous adverse effect of heparin‐induced thrombocytopenia." @default.
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- W4297991569 date "2022-12-01" @default.
- W4297991569 modified "2023-10-18" @default.
- W4297991569 title "Synthesis of a Systematic 64‐Membered Heparan Sulfate Tetrasaccharide Library" @default.
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- W4297991569 doi "https://doi.org/10.1002/ange.202211985" @default.
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