Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297995825> ?p ?o ?g. }
- W4297995825 endingPage "129013" @default.
- W4297995825 startingPage "129013" @default.
- W4297995825 abstract "In this Letter we describe structure-activity relationship (SAR) studies conducted in five distinct regions of a new 2-amino-N-phenylacetamides series of Slack potassium channel inhibitors exemplified by recently disclosed high-throughput screening (HTS) hit VU0606170 (4). New analogs were screened in a thallium (Tl+) flux assay in HEK-293 cells stably expressing wild-type human (WT) Slack. Selected analogs were screened in Tl+ flux versus A934T Slack and other Slo family members Slick and Maxi-K and evaluated in whole-cell electrophysiology (EP) assays using an automated patch clamp system. Results revealed the series to have flat SAR with significant structural modifications resulting in a loss of Slack activity. More minor changes led to compounds with Slack activity and Slo family selectivity similar to the HTS hit." @default.
- W4297995825 created "2022-10-01" @default.
- W4297995825 creator A5011386500 @default.
- W4297995825 creator A5019625443 @default.
- W4297995825 creator A5031151469 @default.
- W4297995825 creator A5035141596 @default.
- W4297995825 creator A5066930244 @default.
- W4297995825 creator A5074801613 @default.
- W4297995825 creator A5088296018 @default.
- W4297995825 date "2022-11-01" @default.
- W4297995825 modified "2023-10-16" @default.
- W4297995825 title "Structure–activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels" @default.
- W4297995825 cites W1556161696 @default.
- W4297995825 cites W1558757561 @default.
- W4297995825 cites W1696906207 @default.
- W4297995825 cites W1995658722 @default.
- W4297995825 cites W1997765371 @default.
- W4297995825 cites W2007850520 @default.
- W4297995825 cites W2028511100 @default.
- W4297995825 cites W2034651748 @default.
- W4297995825 cites W2036405449 @default.
- W4297995825 cites W2067507638 @default.
- W4297995825 cites W2083402168 @default.
- W4297995825 cites W2085408699 @default.
- W4297995825 cites W2104566960 @default.
- W4297995825 cites W2109637158 @default.
- W4297995825 cites W2129889192 @default.
- W4297995825 cites W2133298085 @default.
- W4297995825 cites W2147817553 @default.
- W4297995825 cites W2172011313 @default.
- W4297995825 cites W2292044276 @default.
- W4297995825 cites W2510712109 @default.
- W4297995825 cites W2566724517 @default.
- W4297995825 cites W2769543408 @default.
- W4297995825 cites W2886700232 @default.
- W4297995825 cites W2909432678 @default.
- W4297995825 cites W2914467114 @default.
- W4297995825 cites W2919213227 @default.
- W4297995825 cites W2930531124 @default.
- W4297995825 cites W2964406987 @default.
- W4297995825 cites W2970042325 @default.
- W4297995825 cites W2972456368 @default.
- W4297995825 cites W2981951225 @default.
- W4297995825 cites W3008292559 @default.
- W4297995825 cites W3011315481 @default.
- W4297995825 cites W3018648844 @default.
- W4297995825 cites W3093470472 @default.
- W4297995825 cites W3134473474 @default.
- W4297995825 cites W4226056305 @default.
- W4297995825 doi "https://doi.org/10.1016/j.bmcl.2022.129013" @default.
- W4297995825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36184030" @default.
- W4297995825 hasPublicationYear "2022" @default.
- W4297995825 type Work @default.
- W4297995825 citedByCount "4" @default.
- W4297995825 countsByYear W42979958252023 @default.
- W4297995825 crossrefType "journal-article" @default.
- W4297995825 hasAuthorship W4297995825A5011386500 @default.
- W4297995825 hasAuthorship W4297995825A5019625443 @default.
- W4297995825 hasAuthorship W4297995825A5031151469 @default.
- W4297995825 hasAuthorship W4297995825A5035141596 @default.
- W4297995825 hasAuthorship W4297995825A5066930244 @default.
- W4297995825 hasAuthorship W4297995825A5074801613 @default.
- W4297995825 hasAuthorship W4297995825A5088296018 @default.
- W4297995825 hasConcept C118792377 @default.
- W4297995825 hasConcept C12554922 @default.
- W4297995825 hasConcept C147944092 @default.
- W4297995825 hasConcept C161790260 @default.
- W4297995825 hasConcept C170493617 @default.
- W4297995825 hasConcept C174510640 @default.
- W4297995825 hasConcept C178790620 @default.
- W4297995825 hasConcept C185592680 @default.
- W4297995825 hasConcept C193042331 @default.
- W4297995825 hasConcept C202751555 @default.
- W4297995825 hasConcept C51323132 @default.
- W4297995825 hasConcept C517785266 @default.
- W4297995825 hasConcept C55493867 @default.
- W4297995825 hasConcept C71240020 @default.
- W4297995825 hasConcept C83743174 @default.
- W4297995825 hasConcept C86803240 @default.
- W4297995825 hasConceptScore W4297995825C118792377 @default.
- W4297995825 hasConceptScore W4297995825C12554922 @default.
- W4297995825 hasConceptScore W4297995825C147944092 @default.
- W4297995825 hasConceptScore W4297995825C161790260 @default.
- W4297995825 hasConceptScore W4297995825C170493617 @default.
- W4297995825 hasConceptScore W4297995825C174510640 @default.
- W4297995825 hasConceptScore W4297995825C178790620 @default.
- W4297995825 hasConceptScore W4297995825C185592680 @default.
- W4297995825 hasConceptScore W4297995825C193042331 @default.
- W4297995825 hasConceptScore W4297995825C202751555 @default.
- W4297995825 hasConceptScore W4297995825C51323132 @default.
- W4297995825 hasConceptScore W4297995825C517785266 @default.
- W4297995825 hasConceptScore W4297995825C55493867 @default.
- W4297995825 hasConceptScore W4297995825C71240020 @default.
- W4297995825 hasConceptScore W4297995825C83743174 @default.
- W4297995825 hasConceptScore W4297995825C86803240 @default.
- W4297995825 hasFunder F4320332161 @default.
- W4297995825 hasFunder F4320332179 @default.
- W4297995825 hasFunder F4320337346 @default.