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- W4297996089 abstract "Diabetes mellitus (DM) is associated with cardiomyopathy. Cardiomyopathy in DM can be from ischemic heart disease or related purely to DM-related myocardial changes. The non-ischemic variant of cardiomyopathy (“diabetic cardiomyopathy”) is in animals related to myocardial hypertrophy, vascular rarefaction, and expansion of the extracellular volume by glycated hemoglobin and fibrosis, and recent echocardiography and magnetic resonance imaging studies in humans are in line with this. In patients with type 2 DM, the left ventricle becomes stiff with concentric remodeling. Myocardial blood flow can increase only threefold during stress, whereas it is normally fivefold. Normally 25% of the myocardium is taken up by the extracellular volume, but in T2DM patients this fraction is increased, in some patients to values >40%. Myocardial fibrosis and maximal myocardial blood flow are inversely correlated, and in some patients virtual “islands of fibrosis” can be detected. These areas probably reflect the fibrotic islands initially described by Rubler et al. (Am J Cardiol 30:595–602, 1972) in the autopsy studies defining “diabetic cardiomyopathy.” Longitudinal studies are now pursued to determine the importance of myocardial hypoperfusion and myocardial fibrosis.KeywordsDiastolic functionEchocardiographyHeart failureHeart failure with reduced ejection fractionHeart failure with preserved ejection fractionMagnetic resonance imagingMyocardial fibrosisMyocardial extracellular volumeMyocardial blood flowGadolinium contrastType 1 diabetes mellitusType 2 diabetes mellitus" @default.
- W4297996089 created "2022-10-01" @default.
- W4297996089 creator A5077078738 @default.
- W4297996089 date "2022-09-30" @default.
- W4297996089 modified "2023-10-14" @default.
- W4297996089 title "Biomarkers of Myocardial Fibrosis in Diabetes, Echocardiography, and Magnetic Resonance Imaging" @default.
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- W4297996089 doi "https://doi.org/10.1007/978-3-031-08014-2_45" @default.
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