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• W4297996282 abstract "Increasing prevalence of T2DM in parallel with increased prevalence of DN, which leading cause of ESRD and T2DM. Albuminuria as a standard biomarker to monitoring the progression of DN know has been challenging due to its ability to detect early renal lesions, monitoring the progression of renal lesion and treatment to prevent ESRD. Discover novel biomarker performed recently to focus on finding ideal marker of a cellular process that can reflect the renal function and histology appearance of DN progression. This chapter presented a review of ELMO-1 as one of the candidates of a biomarker of DN progression, which is reporting in genomic, transcriptomic and metabolomic levels. Previous studies reported genetic variant of ELMO-1 as risk susceptibility for suffering in DN, which replicated in many populations worldwide. In addition, genetically modified animal models and cell lines that have increased ELMO-1 expression reported worsening DN progression. Parallel with animal study, ELMO-1 protein was associated with a marker of declining renal function in T2DM patients.KeywordsAlbuminuriaBiomarkerDiabetic NephropathyELMO-1End-Stage Renal DiseasesExtracellular matrixGenetic VariantIntronStress OxidativeType 2 Diabetes Mellitus" @default.
• W4297996282 created "2022-10-01" @default.
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• W4297996282 date "2022-09-30" @default.
• W4297996282 modified "2023-10-13" @default.
• W4297996282 title "Engulfment and Cell Motility Protein (ELMO)-1 as a Biomarker in Type II Diabetes" @default.
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• W4297996282 doi "https://doi.org/10.1007/978-3-031-08014-2_59" @default.
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