Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297998358> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4297998358 abstract "Thresholding apparent diffusion coefficient (ADC) maps obtained from Diffusion-Weighted-Imaging (DWI) has been proposed for identifying benign lesions that can safely avoid biopsy. The presence of malignancies with high ADC values leads to high thresholds, limiting numbers of avoidable biopsies.We evaluate two previously reported methods for identifying avoidable biopsies: using case-set dependent ADC thresholds that assure 100% sensitivity and using negative likelihood ratio (LR-) with a fixed ADC threshold of 1.50 × 10-3 mm2/s. We evaluated improvements in efficacy obtained by excluding non-mass lesions and lesions with anisotropic intra-lesion morphologic characteristics.Prospective.55 adult females with dense breasts with 69 BI-RADS 4 or 5 lesions (38 malignant, 31 benign) identified on ultrasound and mammography and imaged with MRI prior to biopsy.1.5 T and 3.0 T. DWI.Analysis of DWI, including directional images was done on an ROI basis. ROIs were drawn on DWI images acquired prior to biopsy, referencing all available images including DCE, and mean ADC was measured. Anisotropy was quantified via variation in ADC values in the lesion core across directional DWI images.Improvement in specificity at 100% sensitivity was evaluated with exact McNemar test with 1-sided p-value < 0.05 indicating statistical significance.Using ADC thresholding that assures 100% sensitivity, non-mass and directional variance filtering improved the percent of avoidable biopsies to 42% from baseline of 10% achieved with ADC thresholding alone. Using LR-, filtering improved outcome to 0.06 from baseline 0.25 with ADC thresholding alone. ADC thresholding showed a lower percentage of avoidable biopsies in our cohort than reported in prior studies. When ADC thresholding was supplemented with filtering, the percentage of avoidable biopsies exceeded those of prior studies.Supplementing ADC thresholding with filters excluding non-mass lesions and lesions with anisotropic characteristics on DWI can result in an increased number of avoidable biopsies." @default.
- W4297998358 created "2022-10-01" @default.
- W4297998358 creator A5025334715 @default.
- W4297998358 creator A5026140430 @default.
- W4297998358 creator A5041821390 @default.
- W4297998358 creator A5043565807 @default.
- W4297998358 creator A5056585028 @default.
- W4297998358 creator A5079213983 @default.
- W4297998358 date "2022-09-29" @default.
- W4297998358 modified "2023-10-09" @default.
- W4297998358 title "Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding" @default.
- W4297998358 cites W2014162604 @default.
- W4297998358 cites W2021771053 @default.
- W4297998358 cites W2023125619 @default.
- W4297998358 cites W2034668759 @default.
- W4297998358 cites W2128609253 @default.
- W4297998358 cites W2158126537 @default.
- W4297998358 cites W2192382922 @default.
- W4297998358 cites W2429036347 @default.
- W4297998358 cites W2617223202 @default.
- W4297998358 cites W2768758389 @default.
- W4297998358 cites W2796198656 @default.
- W4297998358 cites W2910373477 @default.
- W4297998358 cites W2980348616 @default.
- W4297998358 cites W2991278755 @default.
- W4297998358 cites W2992025766 @default.
- W4297998358 cites W3033728718 @default.
- W4297998358 cites W3101354928 @default.
- W4297998358 cites W3119003305 @default.
- W4297998358 doi "https://doi.org/10.1186/s12880-022-00897-0" @default.
- W4297998358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36175878" @default.
- W4297998358 hasPublicationYear "2022" @default.
- W4297998358 type Work @default.
- W4297998358 citedByCount "4" @default.
- W4297998358 countsByYear W42979983582022 @default.
- W4297998358 countsByYear W42979983582023 @default.
- W4297998358 crossrefType "journal-article" @default.
- W4297998358 hasAuthorship W4297998358A5025334715 @default.
- W4297998358 hasAuthorship W4297998358A5026140430 @default.
- W4297998358 hasAuthorship W4297998358A5041821390 @default.
- W4297998358 hasAuthorship W4297998358A5043565807 @default.
- W4297998358 hasAuthorship W4297998358A5056585028 @default.
- W4297998358 hasAuthorship W4297998358A5079213983 @default.
- W4297998358 hasBestOaLocation W42979983581 @default.
- W4297998358 hasConcept C105795698 @default.
- W4297998358 hasConcept C115961682 @default.
- W4297998358 hasConcept C126322002 @default.
- W4297998358 hasConcept C126838900 @default.
- W4297998358 hasConcept C143409427 @default.
- W4297998358 hasConcept C149550507 @default.
- W4297998358 hasConcept C154945302 @default.
- W4297998358 hasConcept C186282968 @default.
- W4297998358 hasConcept C191178318 @default.
- W4297998358 hasConcept C2775934546 @default.
- W4297998358 hasConcept C2989005 @default.
- W4297998358 hasConcept C33923547 @default.
- W4297998358 hasConcept C41008148 @default.
- W4297998358 hasConcept C58471807 @default.
- W4297998358 hasConcept C70816921 @default.
- W4297998358 hasConcept C71924100 @default.
- W4297998358 hasConceptScore W4297998358C105795698 @default.
- W4297998358 hasConceptScore W4297998358C115961682 @default.
- W4297998358 hasConceptScore W4297998358C126322002 @default.
- W4297998358 hasConceptScore W4297998358C126838900 @default.
- W4297998358 hasConceptScore W4297998358C143409427 @default.
- W4297998358 hasConceptScore W4297998358C149550507 @default.
- W4297998358 hasConceptScore W4297998358C154945302 @default.
- W4297998358 hasConceptScore W4297998358C186282968 @default.
- W4297998358 hasConceptScore W4297998358C191178318 @default.
- W4297998358 hasConceptScore W4297998358C2775934546 @default.
- W4297998358 hasConceptScore W4297998358C2989005 @default.
- W4297998358 hasConceptScore W4297998358C33923547 @default.
- W4297998358 hasConceptScore W4297998358C41008148 @default.
- W4297998358 hasConceptScore W4297998358C58471807 @default.
- W4297998358 hasConceptScore W4297998358C70816921 @default.
- W4297998358 hasConceptScore W4297998358C71924100 @default.
- W4297998358 hasIssue "1" @default.
- W4297998358 hasLocation W42979983581 @default.
- W4297998358 hasLocation W42979983582 @default.
- W4297998358 hasLocation W42979983583 @default.
- W4297998358 hasOpenAccess W4297998358 @default.
- W4297998358 hasPrimaryLocation W42979983581 @default.
- W4297998358 hasRelatedWork W1961410809 @default.
- W4297998358 hasRelatedWork W2060805405 @default.
- W4297998358 hasRelatedWork W2165768644 @default.
- W4297998358 hasRelatedWork W2571833073 @default.
- W4297998358 hasRelatedWork W2782413369 @default.
- W4297998358 hasRelatedWork W2805352517 @default.
- W4297998358 hasRelatedWork W4200614960 @default.
- W4297998358 hasRelatedWork W4235782454 @default.
- W4297998358 hasRelatedWork W4288174753 @default.
- W4297998358 hasRelatedWork W4310203969 @default.
- W4297998358 hasVolume "22" @default.
- W4297998358 isParatext "false" @default.
- W4297998358 isRetracted "false" @default.
- W4297998358 workType "article" @default.