FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298006161> ?p ?o ?g. }

• W4298006161 abstract "Abstract Following SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with ordinary everyday activities due to weakness, memory lapses, pain, dyspnea, and other unspecific physical complaints. Several investigators have demonstrated that the SARS-CoV-2-related spike glycoprotein (SGP) not only attaches to angiotensin-converting enzyme-2 (ACE-2) receptors but also shows DNA sections highly affine to nicotinic acetylcholine receptors (nAChRs). The nAChR is the principal structure of cholinergic neuromodulation and is responsible for coordinated neuronal network interactions. Nonintrinsic viral nAChR attachment substantially compromises integrative interneuronal communication. This explains the cognitive, neuromuscular, and mood impairment and the vegetative symptoms characterizing post-COVID-19 syndrome. The agonist ligand nicotine shows an up to 30-fold higher affinity for nACHRs than acetylcholine (ACh). We hypothesize that this molecule could extrude the virus from nAChR attachment and pave the way for unimpaired cholinergic signal transmission. Treating several individuals suffering from post-COVID-19 syndrome with a nicotine patch application, we observed an immediately substantial improvement of the symptoms up to complete remission after several days." @default.
• W4298006161 created "2022-10-01" @default.
• W4298006161 creator A5004468488 @default.
• W4298006161 date "2022-09-29" @default.
• W4298006161 modified "2023-09-23" @default.
• W4298006161 title "What is the impact of nicotine on the Post-COVID-19 syndrome - a severe impairment of acetylcholine-orchestrated neuromodulation: A case series" @default.
• W4298006161 cites W1482994761 @default.
• W4298006161 cites W1885500469 @default.
• W4298006161 cites W1968829609 @default.
• W4298006161 cites W1969046853 @default.
• W4298006161 cites W2000796102 @default.
• W4298006161 cites W2030117810 @default.
• W4298006161 cites W2035946761 @default.
• W4298006161 cites W2045309216 @default.
• W4298006161 cites W2049324875 @default.
• W4298006161 cites W2053266420 @default.
• W4298006161 cites W2060488758 @default.
• W4298006161 cites W2076338351 @default.
• W4298006161 cites W2076749095 @default.
• W4298006161 cites W2078865137 @default.
• W4298006161 cites W2091374932 @default.
• W4298006161 cites W2119829080 @default.
• W4298006161 cites W2139053364 @default.
• W4298006161 cites W2142837476 @default.
• W4298006161 cites W2153609942 @default.
• W4298006161 cites W2158087247 @default.
• W4298006161 cites W2315418290 @default.
• W4298006161 cites W3013521296 @default.
• W4298006161 cites W3016170162 @default.
• W4298006161 cites W3018871359 @default.
• W4298006161 cites W3020220390 @default.
• W4298006161 cites W3020296371 @default.
• W4298006161 cites W3021390431 @default.
• W4298006161 cites W3022206014 @default.
• W4298006161 cites W3023547764 @default.
• W4298006161 cites W3031302717 @default.
• W4298006161 cites W3032981909 @default.
• W4298006161 cites W3035586023 @default.
• W4298006161 cites W3035748730 @default.
• W4298006161 cites W3041493976 @default.
• W4298006161 cites W3042376507 @default.
• W4298006161 cites W3044231852 @default.
• W4298006161 cites W3045277594 @default.
• W4298006161 cites W3046563370 @default.
• W4298006161 cites W3046806318 @default.
• W4298006161 cites W3048514840 @default.
• W4298006161 cites W3048626717 @default.
• W4298006161 cites W3082503551 @default.
• W4298006161 cites W3087434490 @default.
• W4298006161 cites W3088060702 @default.
• W4298006161 cites W3092475336 @default.
• W4298006161 cites W3093787452 @default.
• W4298006161 cites W3094085694 @default.
• W4298006161 cites W3094361315 @default.
• W4298006161 cites W3096064145 @default.
• W4298006161 cites W3096947756 @default.
• W4298006161 cites W3106731524 @default.
• W4298006161 cites W3107700148 @default.
• W4298006161 cites W3111677710 @default.
• W4298006161 cites W3111991748 @default.
• W4298006161 cites W3112140970 @default.
• W4298006161 cites W3112595513 @default.
• W4298006161 cites W3113688533 @default.
• W4298006161 cites W3114376391 @default.
• W4298006161 cites W3114729768 @default.
• W4298006161 cites W3120387768 @default.
• W4298006161 cites W3122566052 @default.
• W4298006161 cites W3124108769 @default.
• W4298006161 cites W3128519700 @default.
• W4298006161 cites W3129062455 @default.
• W4298006161 cites W3158155888 @default.
• W4298006161 cites W3158840448 @default.
• W4298006161 cites W3159896249 @default.
• W4298006161 cites W3164435183 @default.
• W4298006161 cites W3164640404 @default.
• W4298006161 cites W3165479483 @default.
• W4298006161 cites W3175972973 @default.
• W4298006161 cites W3186314395 @default.
• W4298006161 cites W4200066927 @default.
• W4298006161 cites W4200253206 @default.
• W4298006161 cites W4200262286 @default.
• W4298006161 cites W4205482613 @default.
• W4298006161 cites W4225750634 @default.
• W4298006161 cites W4234119370 @default.
• W4298006161 cites W4250950851 @default.
• W4298006161 cites W4285552697 @default.
• W4298006161 doi "https://doi.org/10.21203/rs.3.rs-2063399/v1" @default.
• W4298006161 hasPublicationYear "2022" @default.
• W4298006161 type Work @default.
• W4298006161 citedByCount "0" @default.
• W4298006161 crossrefType "posted-content" @default.
• W4298006161 hasAuthorship W4298006161A5004468488 @default.
• W4298006161 hasBestOaLocation W42980061611 @default.
• W4298006161 hasConcept C126322002 @default.
• W4298006161 hasConcept C15744967 @default.
• W4298006161 hasConcept C169760540 @default.
• W4298006161 hasConcept C170493617 @default.
• W4298006161 hasConcept C188987157 @default.
• W4298006161 hasConcept C22885893 @default.
• W4298006161 hasConcept C2775910092 @default.

• next