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- W4298008926 abstract "Continuous powder blending is an essential operation during continuous pharmaceutical manufacturing. However, the complex granular dynamics in the blender is still poorly understood. This study employs a graphic processor unit (GPU) enhanced discrete element method (DEM) to analyse the granular dynamics in a continuous blender. Numerical results indicate that only a small fraction of powder distributes in the upper region of the blender, while most of that distributes in the middle and lower regions. Besides, a higher impeller speed leads to a smaller hold-up mass and a shorter mean residence time. Interestingly, the maximum number of blade passes is achieved at an intermediate impeller speed. There are two distinct regimes during continuous blending: i) a shearing regime at low impeller speeds; and ii) a dynamic regime at high impeller speeds. This study demonstrates that the GPU-enhanced DEM can be a robust tool for analysing powder flow during continuous pharmaceutical manufacturing." @default.
- W4298008926 created "2022-10-01" @default.
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- W4298008926 date "2022-11-01" @default.
- W4298008926 modified "2023-10-14" @default.
- W4298008926 title "Investigation of granular dynamics in a continuous blender using the GPU-enhanced discrete element method" @default.
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- W4298008926 doi "https://doi.org/10.1016/j.powtec.2022.117968" @default.
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