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• W4298009422 endingPage "110029" @default.
• W4298009422 startingPage "110029" @default.
• W4298009422 abstract "Three Co(II) complexes [Co(L1) (I), [Co(L2) H2O] II), and [Co(L3) H2O] ](III), where L1H is 2-(2-Hydroxy-5-Bromo Benzylidine) Hydrazine N-Methyl Carbo-Thioamide, L2H is 2-(2-Hydroxy-5-Chloro Benzylidine) Hydrazine N-Methyl Carbo-Thioamide and L3H is 2-(2-Hydroxy-Phenylethylidine) Hydrazine N-Methyl Carbo-Thioamide were synthesized and spectroscopically characterized using FT-IR, UV-Drs, 1H NMR, 13C NMR, ESI Mass, TGA, Magnetic susceptibility values. Based on these values a tetrahedral geometry is proposed for all the complexes. The DNA binding studies against calf thymus DNA (CT DNA) revealed an intercalative mode of binding has existed between DNA and metal complex and also metal complexes can cleave the supercoiled pBR 322 DNA effectively. The Schiff bases and metal complexes were also examined for antimicrobial studies against bacterial species of two gram-positive and two gram- negative strains and also two fungal strains and observed that complexes showed better activity than a free ligand. Further, the cytotoxic activity of synthesized compounds has been done using MTT assay and found that complexes acted as good anticancer agents against both MCF7 and HeLa cell lines." @default.
• W4298009422 created "2022-10-01" @default.
• W4298009422 creator A5019573455 @default.
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• W4298009422 date "2022-11-01" @default.
• W4298009422 modified "2023-10-07" @default.
• W4298009422 title "Cobalt (II) complexes with N-methyl thio semicarbazide Schiff bases: Synthesis, spectroscopic investigation, cytotoxicity, DNA binding and incision, anti-bacterial and anti-fungal studies" @default.
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• W4298009422 doi "https://doi.org/10.1016/j.inoche.2022.110029" @default.
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