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- W4298058333 abstract "We develop a biophysically realistic model of the nematode C. elegans that includes: (i) its muscle structure and activation, (ii) key connectomic activation circuitry, and (iii) a weighted and time-dynamic proprioception. In combination, we show that these model components can reproduce the complex waveforms exhibited in C. elegans locomotive behaviors, chiefly omega turns. This is achieved via weighted, time-dependent suppression of the proprioceptive signal. Though speculative, such dynamics are biologically plausible due to the presence of neuromodulators which have recently been experimentally implicated in the escape response, which includes an omega turn. This is the first integrated neuromechanical model to reveal a mechanism capable of generating the complex waveforms observed in the behavior of C. elegans, thus contributing to a mathematical framework for understanding how control decisions can be executed at the connectome level in order to produce the full repertoire of observed behaviors." @default.
- W4298058333 created "2022-10-01" @default.
- W4298058333 creator A5032895422 @default.
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- W4298058333 date "2017-07-17" @default.
- W4298058333 modified "2023-09-27" @default.
- W4298058333 title "The control structure of the nematode Caenorhabditis elegans: neuro-sensory integration and propioceptive feedback" @default.
- W4298058333 doi "https://doi.org/10.48550/arxiv.1707.05359" @default.
- W4298058333 hasPublicationYear "2017" @default.
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