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- W4298076324 abstract "Both short interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate the repression of specific sequences of mRNA through the RNA interference pathway. In the last years several experiments have supported the hypothesis that siRNAs and miRNAs may be functionally interchangeable, at least in cultured cells. In this work we verify that this hypothesis is also supported by a computational evidence. We show that a method specifically trained to predict the activity of the exogenous siRNAs assigns a high silencing level to experimentally determined human miRNAs. This result not only supports the idea of siRNAs and miRNAs equivalence but indicates that it is possible to use computational tools developed using synthetic small interference RNAs to investigate endogenous miRNAs." @default.
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- W4298076324 date "2007-05-16" @default.
- W4298076324 modified "2023-09-26" @default.
- W4298076324 title "In silico evidence of the relationship between miRNAs and siRNAs" @default.
- W4298076324 doi "https://doi.org/10.48550/arxiv.0705.2355" @default.
- W4298076324 hasPublicationYear "2007" @default.
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