Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298080101> ?p ?o ?g. }
- W4298080101 abstract "Summary Sex chromosome dosage compensation is a model to understand the coordinated regulation of transcription, however the advanced age of the sex chromosomes in model systems make it difficult to study how the complex regulatory mechanisms underlying chromosome-wide dosage compensation can evolve. The sex chromosomes of Poecilia picta have undergone recent and rapid divergence, resulting in widespread gene loss on the male Y, coupled with complete X chromosome dosage compensation, the first case reported in a fish. The de novo origin of a novel dosage compensation system presents a unique opportunity to discover new mechanisms of gene regulation and their evolutionary origins. By combining a new chromosome-level assembly of P. picta with whole-genome bisulfite sequencing and RNA-Seq data, we determine that the binding motif of Yin Yang 1 (YY1) is associated with male hypomethylated regions on the X, but not the autosomes. The male-specific hypomethylation of these motifs offers a putative model for male specific upregulation of genes on the X. These YY1 motifs are the result of a recent and rapid repetitive element expansion on the P. picta X chromosome, which is absent in closely related species that lack dosage compensation. Taken together, our results present compelling support that a disruptive wave of repetitive element insertions carrying YY1 motifs resulted in the remodeling of the X chromosome epigenomic landscape and the de novo origin of a new dosage compensation mechanism." @default.
- W4298080101 created "2022-10-01" @default.
- W4298080101 creator A5017814963 @default.
- W4298080101 creator A5027920050 @default.
- W4298080101 creator A5065185968 @default.
- W4298080101 creator A5084022836 @default.
- W4298080101 creator A5087634551 @default.
- W4298080101 date "2022-09-30" @default.
- W4298080101 modified "2023-09-27" @default.
- W4298080101 title "Transposon wave remodelled the epigenomic landscape in the rapid evolution of a novel X chromosome dosage compensation mechanism" @default.
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