FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298086912> ?p ?o ?g. }

• W4298086912 endingPage "e0275451" @default.
• W4298086912 startingPage "e0275451" @default.
• W4298086912 abstract "Introduction In geriatric patients, hypotension is often reported after general anesthesia induction using propofol. Remimazolam is a novel short-acting sedative. However, the incidence of hypotension after general anesthesia induction using remimazolam in geriatric patients remains unclear. This study aims to compare the incidence of hypotension associated with remimazolam and propofol in patients aged ≥80 years. Methods This single-center, double-blind, randomized, two-arm parallel group, standard treatment-controlled, interventional clinical trial will include 90 patients aged ≥80 years undergoing elective surgery under general anesthesia who will be randomized to receive remimazolam or propofol for induction. The primary outcome is the incidence of hypotension after general anesthesia induction, occurring between the start of drug administration and 3 min after intubation. We define hypotension as mean blood pressure <65 mmHg. The primary outcome will be analyzed using the full analysis set. The incidence of hypotension in the two groups will be compared using the Mantel-Haenszel χ2 test. Subgroup analysis of the primary outcome will be performed based on the Charlson comorbidity index, clinical frailty scale, hypertension in the ward, and age. Secondary outcomes will be analyzed using the Fisher’s exact test, Student’s t test, and Mann–Whitney U test, as appropriate. Logistic regression analysis will be performed to explore the factors associated with the incidence of hypotension after anesthesia induction. Discussion Our trial will determine the efficacy of remimazolam in preventing hypotension and provide evidence on the usefulness of remimazolam for ensuring hemodynamic stability during general anesthesia induction in geriatric patients. Trial registration The study has been registered with UMIN Clinical Trials Registry ( UMIN000042587 ), on June 30, 2021." @default.
• W4298086912 created "2022-10-01" @default.
• W4298086912 creator A5006900367 @default.
• W4298086912 creator A5016891958 @default.
• W4298086912 creator A5018635198 @default.
• W4298086912 creator A5032761079 @default.
• W4298086912 creator A5035284160 @default.
• W4298086912 creator A5066127303 @default.
• W4298086912 creator A5039036510 @default.
• W4298086912 date "2022-09-30" @default.
• W4298086912 modified "2023-10-18" @default.
• W4298086912 title "Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial" @default.
• W4298086912 cites W1939265809 @default.
• W4298086912 cites W1964135143 @default.
• W4298086912 cites W1966653619 @default.
• W4298086912 cites W1977358910 @default.
• W4298086912 cites W2012293219 @default.
• W4298086912 cites W2017675146 @default.
• W4298086912 cites W2031407102 @default.
• W4298086912 cites W2068469916 @default.
• W4298086912 cites W2073636014 @default.
• W4298086912 cites W2075367223 @default.
• W4298086912 cites W2076328855 @default.
• W4298086912 cites W2088466911 @default.
• W4298086912 cites W2095652178 @default.
• W4298086912 cites W2121656227 @default.
• W4298086912 cites W2127719426 @default.
• W4298086912 cites W2142823558 @default.
• W4298086912 cites W2164186760 @default.
• W4298086912 cites W2171811563 @default.
• W4298086912 cites W2345948647 @default.
• W4298086912 cites W2346224271 @default.
• W4298086912 cites W2484729923 @default.
• W4298086912 cites W2724263026 @default.
• W4298086912 cites W2809427753 @default.
• W4298086912 cites W2884479308 @default.
• W4298086912 cites W2915487727 @default.
• W4298086912 cites W2957038622 @default.
• W4298086912 cites W2998786011 @default.
• W4298086912 cites W3011583979 @default.
• W4298086912 cites W3015486573 @default.
• W4298086912 cites W3016871582 @default.
• W4298086912 cites W3024474933 @default.
• W4298086912 cites W3157160216 @default.
• W4298086912 cites W3179504841 @default.
• W4298086912 cites W3200253919 @default.
• W4298086912 cites W4244788991 @default.
• W4298086912 cites W4295192786 @default.
• W4298086912 doi "https://doi.org/10.1371/journal.pone.0275451" @default.
• W4298086912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36178909" @default.
• W4298086912 hasPublicationYear "2022" @default.
• W4298086912 type Work @default.
• W4298086912 citedByCount "1" @default.
• W4298086912 countsByYear W42980869122023 @default.
• W4298086912 crossrefType "journal-article" @default.
• W4298086912 hasAuthorship W4298086912A5006900367 @default.
• W4298086912 hasAuthorship W4298086912A5016891958 @default.
• W4298086912 hasAuthorship W4298086912A5018635198 @default.
• W4298086912 hasAuthorship W4298086912A5032761079 @default.
• W4298086912 hasAuthorship W4298086912A5035284160 @default.
• W4298086912 hasAuthorship W4298086912A5039036510 @default.
• W4298086912 hasAuthorship W4298086912A5066127303 @default.
• W4298086912 hasBestOaLocation W42980869121 @default.
• W4298086912 hasConcept C120665830 @default.
• W4298086912 hasConcept C121332964 @default.
• W4298086912 hasConcept C126322002 @default.
• W4298086912 hasConcept C141071460 @default.
• W4298086912 hasConcept C168563851 @default.
• W4298086912 hasConcept C191093355 @default.
• W4298086912 hasConcept C2776277131 @default.
• W4298086912 hasConcept C42219234 @default.
• W4298086912 hasConcept C535046627 @default.
• W4298086912 hasConcept C61511704 @default.
• W4298086912 hasConcept C71924100 @default.
• W4298086912 hasConcept C84393581 @default.
• W4298086912 hasConceptScore W4298086912C120665830 @default.
• W4298086912 hasConceptScore W4298086912C121332964 @default.
• W4298086912 hasConceptScore W4298086912C126322002 @default.
• W4298086912 hasConceptScore W4298086912C141071460 @default.
• W4298086912 hasConceptScore W4298086912C168563851 @default.
• W4298086912 hasConceptScore W4298086912C191093355 @default.
• W4298086912 hasConceptScore W4298086912C2776277131 @default.
• W4298086912 hasConceptScore W4298086912C42219234 @default.
• W4298086912 hasConceptScore W4298086912C535046627 @default.
• W4298086912 hasConceptScore W4298086912C61511704 @default.
• W4298086912 hasConceptScore W4298086912C71924100 @default.
• W4298086912 hasConceptScore W4298086912C84393581 @default.
• W4298086912 hasIssue "9" @default.
• W4298086912 hasLocation W42980869121 @default.
• W4298086912 hasLocation W42980869122 @default.
• W4298086912 hasLocation W42980869123 @default.
• W4298086912 hasOpenAccess W4298086912 @default.
• W4298086912 hasPrimaryLocation W42980869121 @default.
• W4298086912 hasRelatedWork W2022324825 @default.
• W4298086912 hasRelatedWork W2085967586 @default.
• W4298086912 hasRelatedWork W2352665980 @default.
• W4298086912 hasRelatedWork W2367490127 @default.
• W4298086912 hasRelatedWork W2367617216 @default.

• next