Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298087952> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4298087952 endingPage "10400" @default.
- W4298087952 startingPage "10395" @default.
- W4298087952 abstract "Objective Bilirubin-induced neurotoxicity is mediated by the fraction of total serum bilirubin (TSB) not bound to albumin (Bf). Unbound free fatty acids (FFAu) generated from lipid emulsions compete with bilirubin for albumin binding, increasing Bf. Soy-based (IL) and soy-MCT-olive-fish oil-based (SMOF) lipid emulsions contain different fatty acids with distinct albumin binding affinities. IL increases Bf in preterm infants, but the effects of SMOF on Bf are not known. Our objective was to compare changes in TSB, Bf, FFAu, and response to phototherapy in preterm infants receiving SMOF and IL. We hypothesized that SMOF would be associated with lower Bf and better response to phototherapy than IL.Methods Very preterm and low birth weight infants (<1500 g, <32 weeks) were infused with IL (n = 20) or SMOF (n = 20) as prescribed by providers. Phototherapy was prescribed using the standard care practice. FFAu profiles and levels, TSB, and Bf were measured on 0, 1, 2, and 3 g/kg/day of lipid infusion and at the initiation and termination of phototherapy. TSB was analyzed in the clinical laboratory using the diazo technique. FFAu and Bf were measured using fluorescent probes.Results Escalating doses of IL and SMOF increased FFAu levels and Bf, but not TSB. Phototherapy did not significantly decrease Bf for infants receiving either lipid. IL-treated infants had higher levels of unbound linoleic acid, and SMOF-treated infants had higher unbound arachidonic, oleic, and docosahexaenoic acids.Conclusions IL and SMOF both increase Bf similarly, and phototherapy does not significantly affect Bf for infants receiving them." @default.
- W4298087952 created "2022-10-01" @default.
- W4298087952 creator A5006192005 @default.
- W4298087952 creator A5011717842 @default.
- W4298087952 creator A5029966336 @default.
- W4298087952 creator A5058260405 @default.
- W4298087952 creator A5078027978 @default.
- W4298087952 creator A5084395563 @default.
- W4298087952 date "2022-09-29" @default.
- W4298087952 modified "2023-09-29" @default.
- W4298087952 title "Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants" @default.
- W4298087952 cites W1587010377 @default.
- W4298087952 cites W1978542133 @default.
- W4298087952 cites W1987937465 @default.
- W4298087952 cites W1996615898 @default.
- W4298087952 cites W1998018336 @default.
- W4298087952 cites W2002842565 @default.
- W4298087952 cites W2007804932 @default.
- W4298087952 cites W2027674242 @default.
- W4298087952 cites W2052905752 @default.
- W4298087952 cites W2067950565 @default.
- W4298087952 cites W2102029794 @default.
- W4298087952 cites W2106308253 @default.
- W4298087952 cites W2135805245 @default.
- W4298087952 cites W2157154175 @default.
- W4298087952 cites W2326036034 @default.
- W4298087952 cites W2350379238 @default.
- W4298087952 cites W2394660565 @default.
- W4298087952 cites W2572908265 @default.
- W4298087952 cites W2575862550 @default.
- W4298087952 cites W2808034241 @default.
- W4298087952 cites W3022195135 @default.
- W4298087952 cites W3035317039 @default.
- W4298087952 cites W3108215388 @default.
- W4298087952 cites W3216903508 @default.
- W4298087952 cites W4301372139 @default.
- W4298087952 doi "https://doi.org/10.1080/14767058.2022.2128656" @default.
- W4298087952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36176060" @default.
- W4298087952 hasPublicationYear "2022" @default.
- W4298087952 type Work @default.
- W4298087952 citedByCount "0" @default.
- W4298087952 crossrefType "journal-article" @default.
- W4298087952 hasAuthorship W4298087952A5006192005 @default.
- W4298087952 hasAuthorship W4298087952A5011717842 @default.
- W4298087952 hasAuthorship W4298087952A5029966336 @default.
- W4298087952 hasAuthorship W4298087952A5058260405 @default.
- W4298087952 hasAuthorship W4298087952A5078027978 @default.
- W4298087952 hasAuthorship W4298087952A5084395563 @default.
- W4298087952 hasConcept C126322002 @default.
- W4298087952 hasConcept C181199279 @default.
- W4298087952 hasConcept C185592680 @default.
- W4298087952 hasConcept C19038510 @default.
- W4298087952 hasConcept C2776125364 @default.
- W4298087952 hasConcept C2777171753 @default.
- W4298087952 hasConcept C2777513400 @default.
- W4298087952 hasConcept C2778078955 @default.
- W4298087952 hasConcept C2780809830 @default.
- W4298087952 hasConcept C2781403372 @default.
- W4298087952 hasConcept C543025807 @default.
- W4298087952 hasConcept C55493867 @default.
- W4298087952 hasConcept C71924100 @default.
- W4298087952 hasConceptScore W4298087952C126322002 @default.
- W4298087952 hasConceptScore W4298087952C181199279 @default.
- W4298087952 hasConceptScore W4298087952C185592680 @default.
- W4298087952 hasConceptScore W4298087952C19038510 @default.
- W4298087952 hasConceptScore W4298087952C2776125364 @default.
- W4298087952 hasConceptScore W4298087952C2777171753 @default.
- W4298087952 hasConceptScore W4298087952C2777513400 @default.
- W4298087952 hasConceptScore W4298087952C2778078955 @default.
- W4298087952 hasConceptScore W4298087952C2780809830 @default.
- W4298087952 hasConceptScore W4298087952C2781403372 @default.
- W4298087952 hasConceptScore W4298087952C543025807 @default.
- W4298087952 hasConceptScore W4298087952C55493867 @default.
- W4298087952 hasConceptScore W4298087952C71924100 @default.
- W4298087952 hasIssue "26" @default.
- W4298087952 hasLocation W42980879521 @default.
- W4298087952 hasLocation W42980879522 @default.
- W4298087952 hasOpenAccess W4298087952 @default.
- W4298087952 hasPrimaryLocation W42980879521 @default.
- W4298087952 hasRelatedWork W1516451194 @default.
- W4298087952 hasRelatedWork W1969778622 @default.
- W4298087952 hasRelatedWork W2053687970 @default.
- W4298087952 hasRelatedWork W2062497355 @default.
- W4298087952 hasRelatedWork W2114589635 @default.
- W4298087952 hasRelatedWork W2357632917 @default.
- W4298087952 hasRelatedWork W2486996905 @default.
- W4298087952 hasRelatedWork W2806072869 @default.
- W4298087952 hasRelatedWork W3213364865 @default.
- W4298087952 hasRelatedWork W1636533859 @default.
- W4298087952 hasVolume "35" @default.
- W4298087952 isParatext "false" @default.
- W4298087952 isRetracted "false" @default.
- W4298087952 workType "article" @default.