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• W4298088908 endingPage "519" @default.
• W4298088908 startingPage "515" @default.
• W4298088908 abstract "Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities. Several genetic, environmental, and immunological factors are known to influence the onset of the disease. MiRNAs have been already considered as potential actors involved in the development and activity of the SLE. Thus, understanding the behavior of these regulators can contribute to clarify the inflammatory process affecting SLE patients. Among miRNAs, miR-125b-5p and miR-9-5p targeting NFKB1 and TRAF6 genes can be involved in the etio-pathogenesis of the disease by modulating inflammation. In this study we evaluated miR-9-5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls. MiRNAs and gene target expression have been evaluated by using RT-PCR with specific TaqMan® probes. Both miR-9-5p [Fold Change (FC) = -2.21; p = 0.002] and miR-125b-5p (FC= -3.30; p < 0.0001) and NFKB1 (FC = -1.84; p < 0.001) were downregulated in cSLE patients, while TRAF6 was upregulated (FC = 1.80; p = 0.006) in cSLE patients when compared to controls. A significant correlation was found between miR-125b-5p and its target gene NFKB1 [Spearman (r) = 0.47; p = 0.023]. Our results showed miR-125b-5p and miR-9-5p differential expression in cSLE patients, possibly contributing to better understanding the role of these regulators in cSLE development and disease pathogenesis." @default.
• W4298088908 created "2022-10-01" @default.
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• W4298088908 date "2022-09-29" @default.
• W4298088908 modified "2023-10-13" @default.
• W4298088908 title "Expression of the miR-9-5p, miR-125b-5p and its target gene <i>NFKB1</i> and <i>TRAF6</i> in childhood-onset systemic lupus erythematosus (cSLE)" @default.
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• W4298088908 doi "https://doi.org/10.1080/08916934.2022.2128781" @default.
• W4298088908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36177494" @default.
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