FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298109224> ?p ?o ?g. }

• W4298109224 abstract "Background Clinical implementation of polygenic risk scores (PRS) for precision prevention depends on the utility and barriers primary care physicians (PCPs) perceive to their use. Methods An online survey asked PCPs in a national database about the clinical utility of PRS they perceived for categories of medical decision-making and perceived benefits of and barriers to that use. Latent class analysis (LCA) was used to identify subgroups of PCPs based on response patterns. Results Among 367 respondents (email open rate 10.8%; participation rate 96.3%; completion rate 93.1%), mean (SD) age was 54.9 (12.9) years, 137 (37.3%) were female, and mean (SD) time since medical school graduation was 27.2 (13.3) years. Respondents reported greater perceived utility for more clinical action (e.g., earlier or more intensive screening, preventive medications, or lifestyle modification) for patients with high-risk PRS than for delayed or discontinued prevention actions for low-risk patients ( p <0.001). Respondents most often chose out-of-pocket costs (48%), lack of clinical guidelines (24%), and patient insurance discrimination concerns (22%) as extreme barriers to PRS implementation. LCA identified 3 subclasses of respondents. Skeptics (n=83, 22.6%) endorsed less agreement with individual clinical utilities, saw patient anxiety and insurance discrimination as significant barriers, and agreed less often that PRS could help patients make better health decisions. Learners (n=134, 36.5%) and enthusiasts (n=150, 40.9%) expressed similar levels of agreement that PRS had utility for preventive actions and that PRS could be useful for patient decision-making. Compared with enthusiasts , however, learners perceived greater barriers to the clinical use of PRS. Conclusion PCPs generally endorsed using PRS to guide medical decision-making about preventive care, with a preference for more clinical action over less. Barriers identified suggest interventions to address the needs and concerns of PCPs along the spectrum of acceptance and uptake." @default.
• W4298109224 created "2022-10-01" @default.
• W4298109224 creator A5021507441 @default.
• W4298109224 creator A5033714604 @default.
• W4298109224 creator A5037492627 @default.
• W4298109224 creator A5041851749 @default.
• W4298109224 creator A5064984144 @default.
• W4298109224 creator A5071132604 @default.
• W4298109224 creator A5077524398 @default.
• W4298109224 creator A5081573086 @default.
• W4298109224 creator A5088019493 @default.
• W4298109224 date "2022-09-30" @default.
• W4298109224 modified "2023-10-03" @default.
• W4298109224 title "Benefits and barriers to implementing precision preventive care: results of a national physician survey" @default.
• W4298109224 cites W1046275439 @default.
• W4298109224 cites W1495834265 @default.
• W4298109224 cites W1505038491 @default.
• W4298109224 cites W1995986069 @default.
• W4298109224 cites W2013578576 @default.
• W4298109224 cites W2019102798 @default.
• W4298109224 cites W2030982209 @default.
• W4298109224 cites W2068185353 @default.
• W4298109224 cites W2068640436 @default.
• W4298109224 cites W2079706664 @default.
• W4298109224 cites W2090330784 @default.
• W4298109224 cites W2122447595 @default.
• W4298109224 cites W2122448741 @default.
• W4298109224 cites W2130527146 @default.
• W4298109224 cites W2132328291 @default.
• W4298109224 cites W2147549707 @default.
• W4298109224 cites W2163046331 @default.
• W4298109224 cites W2279270723 @default.
• W4298109224 cites W2519880746 @default.
• W4298109224 cites W2565875026 @default.
• W4298109224 cites W2726396617 @default.
• W4298109224 cites W2780769018 @default.
• W4298109224 cites W2796326845 @default.
• W4298109224 cites W2800797803 @default.
• W4298109224 cites W2886752110 @default.
• W4298109224 cites W2901952863 @default.
• W4298109224 cites W2903698441 @default.
• W4298109224 cites W2946258293 @default.
• W4298109224 cites W2952013316 @default.
• W4298109224 cites W2966091252 @default.
• W4298109224 cites W2980086570 @default.
• W4298109224 cites W2996201549 @default.
• W4298109224 cites W3028329270 @default.
• W4298109224 cites W3032942076 @default.
• W4298109224 cites W3043916034 @default.
• W4298109224 cites W3093299235 @default.
• W4298109224 cites W3102547229 @default.
• W4298109224 cites W3115151307 @default.
• W4298109224 cites W3127721151 @default.
• W4298109224 cites W3156798349 @default.
• W4298109224 cites W3182123521 @default.
• W4298109224 cites W3186788701 @default.
• W4298109224 cites W3197057224 @default.
• W4298109224 cites W3198236323 @default.
• W4298109224 cites W4210399789 @default.
• W4298109224 cites W4210524280 @default.
• W4298109224 cites W4210835581 @default.
• W4298109224 cites W4212792737 @default.
• W4298109224 cites W4220740285 @default.
• W4298109224 cites W4220850713 @default.
• W4298109224 cites W4221058654 @default.
• W4298109224 cites W4223619952 @default.
• W4298109224 cites W4223924706 @default.
• W4298109224 cites W4229035861 @default.
• W4298109224 cites W4282834432 @default.
• W4298109224 cites W4285727181 @default.
• W4298109224 cites W4288709987 @default.
• W4298109224 cites W4292018391 @default.
• W4298109224 doi "https://doi.org/10.1101/2022.09.29.22280488" @default.
• W4298109224 hasPublicationYear "2022" @default.
• W4298109224 type Work @default.
• W4298109224 citedByCount "0" @default.
• W4298109224 crossrefType "posted-content" @default.
• W4298109224 hasAuthorship W4298109224A5021507441 @default.
• W4298109224 hasAuthorship W4298109224A5033714604 @default.
• W4298109224 hasAuthorship W4298109224A5037492627 @default.
• W4298109224 hasAuthorship W4298109224A5041851749 @default.
• W4298109224 hasAuthorship W4298109224A5064984144 @default.
• W4298109224 hasAuthorship W4298109224A5071132604 @default.
• W4298109224 hasAuthorship W4298109224A5077524398 @default.
• W4298109224 hasAuthorship W4298109224A5081573086 @default.
• W4298109224 hasAuthorship W4298109224A5088019493 @default.
• W4298109224 hasBestOaLocation W42981092241 @default.
• W4298109224 hasConcept C160735492 @default.
• W4298109224 hasConcept C162324750 @default.
• W4298109224 hasConcept C2524010 @default.
• W4298109224 hasConcept C2779529714 @default.
• W4298109224 hasConcept C2984730517 @default.
• W4298109224 hasConcept C33923547 @default.
• W4298109224 hasConcept C50522688 @default.
• W4298109224 hasConcept C512399662 @default.
• W4298109224 hasConcept C71924100 @default.
• W4298109224 hasConceptScore W4298109224C160735492 @default.
• W4298109224 hasConceptScore W4298109224C162324750 @default.
• W4298109224 hasConceptScore W4298109224C2524010 @default.
• W4298109224 hasConceptScore W4298109224C2779529714 @default.

• next