FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298122282> ?p ?o ?g. }

• W4298122282 endingPage "1081" @default.
• W4298122282 startingPage "1074" @default.
• W4298122282 abstract "Abstract Objective To compare steroid profiles in the follicular fluid (FF) from women homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C>T mutation and wildtype controls and to correlate it with the folic acid administration scheme applied at the time of oocyte retrieval. Design Retrospective single center study. Subjects and Methods Infertile patients treated by using assisted reproductive techniques were genotyped routinely for the MTHFR 677C>T mutation. In 2006 they had received folic acid supplementation doses of 400 µg daily per os. This group was designated Group-400 (n = 10). From 2008 onwards, all of our infertility patients received a daily dose of 800 µg folic acid per os. Women from this group were designated Group-800 (n = 28). FF were collected and a panel of steroid hormones (estradiol, estrone, estriol, cortisol, progesterone, 17-OH progesterone, testosterone, androstenedione, aldosterone, DHEA, and DHEA-S) was measured by isotope dilution liquid chromatography-tandem mass spectrometry employing atmospheric pressure photo ionization (APPI). Results In Group-400, the FF hormone profile confirmed a significant reduction of estradiol in homozygous 677TT carriers (0.52 ± 0.08-fold, exact p = 0.032) and for the first time also revealed significantly reduced estriol concentrations in these individuals (0.54 ± 0.05-fold, p = 0.016), as compared to wildtype controls. In Group-800, no significant differences were found for concentrations of any of the steroid hormones between homozygous 677TT carriers and wildtype controls. Conclusions The current findings support and extend previous reports on reduced concentrations of specific steroid hormones in follicular fluids of homozygous MTHFR 677C>T mutation carriers. The restoration of the FF hormone profile by elevated-dose folic acid supplementation might impact performing ART in infertile women with the MTHFR 677TT-genotype. Further adequately powered studies are necessary to verify our finding and to demonstrate the clinical effect of enhanced folic supplementation on ovarian function." @default.
• W4298122282 created "2022-10-01" @default.
• W4298122282 creator A5001955282 @default.
• W4298122282 creator A5022390919 @default.
• W4298122282 creator A5045208618 @default.
• W4298122282 creator A5048030193 @default.
• W4298122282 creator A5061582826 @default.
• W4298122282 creator A5078142175 @default.
• W4298122282 creator A5085188886 @default.
• W4298122282 creator A5033805866 @default.
• W4298122282 date "2022-09-30" @default.
• W4298122282 modified "2023-09-26" @default.
• W4298122282 title "Reduced Steroid Synthesis in the Follicular Fluid of MTHFR 677TT Mutation Carriers: Effects of Increased Folic Acid Administration" @default.
• W4298122282 cites W1482397881 @default.
• W4298122282 cites W1548614191 @default.
• W4298122282 cites W1951825856 @default.
• W4298122282 cites W1987073591 @default.
• W4298122282 cites W1987985529 @default.
• W4298122282 cites W1988653396 @default.
• W4298122282 cites W1996234542 @default.
• W4298122282 cites W2003081461 @default.
• W4298122282 cites W2018101989 @default.
• W4298122282 cites W2029381990 @default.
• W4298122282 cites W2037772928 @default.
• W4298122282 cites W2043840979 @default.
• W4298122282 cites W2050075673 @default.
• W4298122282 cites W2066461313 @default.
• W4298122282 cites W2066688265 @default.
• W4298122282 cites W2073818565 @default.
• W4298122282 cites W2079159618 @default.
• W4298122282 cites W2088524452 @default.
• W4298122282 cites W2100409392 @default.
• W4298122282 cites W2102203236 @default.
• W4298122282 cites W2104064852 @default.
• W4298122282 cites W2128085163 @default.
• W4298122282 cites W2133589791 @default.
• W4298122282 cites W2149224117 @default.
• W4298122282 cites W2150147985 @default.
• W4298122282 cites W2160034230 @default.
• W4298122282 cites W2163768600 @default.
• W4298122282 cites W2165715420 @default.
• W4298122282 cites W2168275698 @default.
• W4298122282 cites W2300405932 @default.
• W4298122282 cites W2395082718 @default.
• W4298122282 cites W2395535398 @default.
• W4298122282 cites W2463238295 @default.
• W4298122282 cites W2616967758 @default.
• W4298122282 cites W2726892492 @default.
• W4298122282 cites W2747943965 @default.
• W4298122282 cites W290844885 @default.
• W4298122282 cites W2954861419 @default.
• W4298122282 cites W3159374249 @default.
• W4298122282 cites W3215145869 @default.
• W4298122282 doi "https://doi.org/10.1055/a-1791-9358" @default.
• W4298122282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36186148" @default.
• W4298122282 hasPublicationYear "2022" @default.
• W4298122282 type Work @default.
• W4298122282 citedByCount "0" @default.
• W4298122282 crossrefType "journal-article" @default.
• W4298122282 hasAuthorship W4298122282A5001955282 @default.
• W4298122282 hasAuthorship W4298122282A5022390919 @default.
• W4298122282 hasAuthorship W4298122282A5033805866 @default.
• W4298122282 hasAuthorship W4298122282A5045208618 @default.
• W4298122282 hasAuthorship W4298122282A5048030193 @default.
• W4298122282 hasAuthorship W4298122282A5061582826 @default.
• W4298122282 hasAuthorship W4298122282A5078142175 @default.
• W4298122282 hasAuthorship W4298122282A5085188886 @default.
• W4298122282 hasBestOaLocation W42981222821 @default.
• W4298122282 hasConcept C104317684 @default.
• W4298122282 hasConcept C126322002 @default.
• W4298122282 hasConcept C134018914 @default.
• W4298122282 hasConcept C180754005 @default.
• W4298122282 hasConcept C185592680 @default.
• W4298122282 hasConcept C2777164284 @default.
• W4298122282 hasConcept C2777335581 @default.
• W4298122282 hasConcept C2778656385 @default.
• W4298122282 hasConcept C2779279991 @default.
• W4298122282 hasConcept C43563269 @default.
• W4298122282 hasConcept C55493867 @default.
• W4298122282 hasConcept C71315377 @default.
• W4298122282 hasConcept C71924100 @default.
• W4298122282 hasConceptScore W4298122282C104317684 @default.
• W4298122282 hasConceptScore W4298122282C126322002 @default.
• W4298122282 hasConceptScore W4298122282C134018914 @default.
• W4298122282 hasConceptScore W4298122282C180754005 @default.
• W4298122282 hasConceptScore W4298122282C185592680 @default.
• W4298122282 hasConceptScore W4298122282C2777164284 @default.
• W4298122282 hasConceptScore W4298122282C2777335581 @default.
• W4298122282 hasConceptScore W4298122282C2778656385 @default.
• W4298122282 hasConceptScore W4298122282C2779279991 @default.
• W4298122282 hasConceptScore W4298122282C43563269 @default.
• W4298122282 hasConceptScore W4298122282C55493867 @default.
• W4298122282 hasConceptScore W4298122282C71315377 @default.
• W4298122282 hasConceptScore W4298122282C71924100 @default.
• W4298122282 hasFunder F4320337381 @default.
• W4298122282 hasFunder F4320337611 @default.
• W4298122282 hasIssue "10" @default.
• W4298122282 hasLocation W42981222821 @default.

• next