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• W4298128321 startingPage "106199" @default.
• W4298128321 abstract "The uterus and breasts are hormone-responsive tissues. Progesterone and estradiol regulate gonadotropin secretion, prepare the endometrium for implantation, maintain pregnancy, and regulate the differentiation of breast tissue. Dysregulation of these hormones causes endometriosis, endometrial cancer, and breast cancer, damaging the physical and mental health of women. Emerging evidence has shown that progesterone resistance or elevated progesterone activity is the primary hormonal substrate of these diseases. Since progesterone acts through its specific nuclear receptor, the abnormal expression of the progesterone receptor (PR) dysregulates progesterone function. This review discusses the regulatory mechanisms of PR expression in patients with endometriosis, and endometrial or breast cancer, including estrogen, polymorphisms, transcription factors, epigenetics, and the ubiquitin-proteasome system. (1) Estrogen promotes the expression of PRA (a PR isoform) mRNA and protein through the interaction of estrogen receptors (ERs) and Sp1 with half-ERE/Sp1 binding sites. ERs also affect the binding of Sp1 and Sp1 sites to promote the expression of PRB (another PR isoform)(2) PR polymorphisms, mainly PROGINS and + 331 G/A polymorphism, regulate PR expression by affecting DNA methylation and transcription factor binding. (3) The influence of epigenetic alterations on PR expression occurs through DNA methylation, histone modification, and microRNA. (4) As one of the main protein degradation pathways in vivo, the ubiquitin-proteasome system (UPS) regulates PR expression by participating in protein degradation. These mechanisms may provide new molecular targets for diagnosing and treating endometriosis, endometrial, and breast cancer." @default.
• W4298128321 created "2022-10-01" @default.
• W4298128321 creator A5009694232 @default.
• W4298128321 creator A5039325472 @default.
• W4298128321 creator A5054054642 @default.
• W4298128321 creator A5072941747 @default.
• W4298128321 date "2023-03-01" @default.
• W4298128321 modified "2023-10-16" @default.
• W4298128321 title "Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system" @default.
• W4298128321 cites W144423133 @default.
• W4298128321 cites W1483942674 @default.
• W4298128321 cites W1494864623 @default.
• W4298128321 cites W1512367340 @default.
• W4298128321 cites W1520583513 @default.
• W4298128321 cites W1554236013 @default.
• W4298128321 cites W1566559214 @default.
• W4298128321 cites W1569704074 @default.
• W4298128321 cites W1578964543 @default.
• W4298128321 cites W1831033366 @default.
• W4298128321 cites W1933086732 @default.
• W4298128321 cites W1963928942 @default.
• W4298128321 cites W1967064280 @default.
• W4298128321 cites W1967997862 @default.
• W4298128321 cites W1968161876 @default.
• W4298128321 cites W1969687617 @default.
• W4298128321 cites W1970078194 @default.
• W4298128321 cites W1972385372 @default.
• W4298128321 cites W1974171707 @default.
• W4298128321 cites W1975134052 @default.
• W4298128321 cites W1978718059 @default.
• W4298128321 cites W1980636583 @default.
• W4298128321 cites W1984433201 @default.
• W4298128321 cites W1985180051 @default.
• W4298128321 cites W1985734239 @default.
• W4298128321 cites W1987283598 @default.
• W4298128321 cites W1987417875 @default.
• W4298128321 cites W1988919009 @default.
• W4298128321 cites W1989779077 @default.
• W4298128321 cites W1990529844 @default.
• W4298128321 cites W1994505064 @default.
• W4298128321 cites W1996446365 @default.
• W4298128321 cites W1997535745 @default.
• W4298128321 cites W2000887060 @default.
• W4298128321 cites W2001889167 @default.
• W4298128321 cites W2002098580 @default.
• W4298128321 cites W2003054629 @default.
• W4298128321 cites W2003778314 @default.
• W4298128321 cites W2010311608 @default.
• W4298128321 cites W2010754935 @default.
• W4298128321 cites W2011214996 @default.
• W4298128321 cites W2012904520 @default.
• W4298128321 cites W2015279480 @default.
• W4298128321 cites W2015777453 @default.
• W4298128321 cites W2016921243 @default.
• W4298128321 cites W2018861408 @default.
• W4298128321 cites W2021361522 @default.
• W4298128321 cites W2025995094 @default.
• W4298128321 cites W2027953312 @default.
• W4298128321 cites W2028462302 @default.
• W4298128321 cites W2030899358 @default.
• W4298128321 cites W2032902305 @default.
• W4298128321 cites W2032903445 @default.
• W4298128321 cites W2034552774 @default.
• W4298128321 cites W2038507723 @default.
• W4298128321 cites W2039737646 @default.
• W4298128321 cites W2039744525 @default.
• W4298128321 cites W2040762618 @default.
• W4298128321 cites W2042443221 @default.
• W4298128321 cites W2044438341 @default.
• W4298128321 cites W2044447016 @default.
• W4298128321 cites W2045362835 @default.
• W4298128321 cites W2051981149 @default.
• W4298128321 cites W2052245648 @default.
• W4298128321 cites W2054555143 @default.
• W4298128321 cites W2055375920 @default.
• W4298128321 cites W2056357500 @default.
• W4298128321 cites W2057550432 @default.
• W4298128321 cites W2059664345 @default.
• W4298128321 cites W2068638854 @default.
• W4298128321 cites W2069512527 @default.
• W4298128321 cites W2069554427 @default.
• W4298128321 cites W2069877304 @default.
• W4298128321 cites W2070777085 @default.
• W4298128321 cites W2072339938 @default.
• W4298128321 cites W2074966947 @default.
• W4298128321 cites W2075005022 @default.
• W4298128321 cites W2076940012 @default.
• W4298128321 cites W2077579184 @default.
• W4298128321 cites W2078551011 @default.
• W4298128321 cites W2078802143 @default.
• W4298128321 cites W2081427413 @default.
• W4298128321 cites W2083063093 @default.
• W4298128321 cites W2084363318 @default.
• W4298128321 cites W2086067796 @default.
• W4298128321 cites W2086551998 @default.
• W4298128321 cites W2089876832 @default.
• W4298128321 cites W2091717918 @default.
• W4298128321 cites W2097951173 @default.

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