Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298132701> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4298132701 endingPage "115088" @default.
- W4298132701 startingPage "115088" @default.
- W4298132701 abstract "d-Cysteine (d-Cys) is metabolized to hydrogen sulfide (H2S) by d-amino acid oxidase (DAO)/3-mercaptopyruvate sulfurtransferase pathway. The pathway is required for H2S supplementation that ameliorates acute kidney injury after the oral administration of d-Cys in mice. However, whether the rate-limiting activity of DAO regulates the tissue-selectivity or the extent of d-Cys degradation and H2S supplementation remains unclear. Here, to analyze the levels of d-Cys and H2S, we use two derivatization methods, a new method with no detectable isomerization of Cys and an established method for H2S. The derivatives were determined by LC/MS using a C18 column. With the methods, we show that inhibition of DAO significantly suppresses the H2S supplementation and d-Cys degradation in the mouse kidney. Additionally, we found that d-Cys is more efficiently metabolized into H2S than l-Cys in the kidney. Our results reveal the utility of the method and support the advantage of d-Cys administration in improving the supply of H2S to the kidneys." @default.
- W4298132701 created "2022-10-01" @default.
- W4298132701 creator A5011606327 @default.
- W4298132701 creator A5020631966 @default.
- W4298132701 creator A5030234326 @default.
- W4298132701 creator A5057899072 @default.
- W4298132701 creator A5062846218 @default.
- W4298132701 creator A5085376569 @default.
- W4298132701 date "2023-01-01" @default.
- W4298132701 modified "2023-10-15" @default.
- W4298132701 title "Precolumn derivatization LC/MS method for observation of efficient hydrogen sulfide supply to the kidney via d-cysteine degradation pathway" @default.
- W4298132701 cites W1513696494 @default.
- W4298132701 cites W1691539505 @default.
- W4298132701 cites W1973583640 @default.
- W4298132701 cites W1982895791 @default.
- W4298132701 cites W1995428934 @default.
- W4298132701 cites W2011683006 @default.
- W4298132701 cites W2012034410 @default.
- W4298132701 cites W2029932670 @default.
- W4298132701 cites W2042577582 @default.
- W4298132701 cites W2068875108 @default.
- W4298132701 cites W2098704998 @default.
- W4298132701 cites W2337369926 @default.
- W4298132701 cites W2411672332 @default.
- W4298132701 cites W2538496561 @default.
- W4298132701 cites W2790868921 @default.
- W4298132701 cites W2896089853 @default.
- W4298132701 cites W2902088943 @default.
- W4298132701 cites W2907974517 @default.
- W4298132701 cites W2915797192 @default.
- W4298132701 cites W2945159151 @default.
- W4298132701 cites W2970443332 @default.
- W4298132701 cites W3157613770 @default.
- W4298132701 cites W3201090175 @default.
- W4298132701 cites W4200224482 @default.
- W4298132701 cites W4213314759 @default.
- W4298132701 doi "https://doi.org/10.1016/j.jpba.2022.115088" @default.
- W4298132701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36215804" @default.
- W4298132701 hasPublicationYear "2023" @default.
- W4298132701 type Work @default.
- W4298132701 citedByCount "1" @default.
- W4298132701 countsByYear W42981327012023 @default.
- W4298132701 crossrefType "journal-article" @default.
- W4298132701 hasAuthorship W4298132701A5011606327 @default.
- W4298132701 hasAuthorship W4298132701A5020631966 @default.
- W4298132701 hasAuthorship W4298132701A5030234326 @default.
- W4298132701 hasAuthorship W4298132701A5057899072 @default.
- W4298132701 hasAuthorship W4298132701A5062846218 @default.
- W4298132701 hasAuthorship W4298132701A5085376569 @default.
- W4298132701 hasBestOaLocation W42981327011 @default.
- W4298132701 hasConcept C126322002 @default.
- W4298132701 hasConcept C178790620 @default.
- W4298132701 hasConcept C179998833 @default.
- W4298132701 hasConcept C181199279 @default.
- W4298132701 hasConcept C185592680 @default.
- W4298132701 hasConcept C2776923573 @default.
- W4298132701 hasConcept C2779201268 @default.
- W4298132701 hasConcept C2780091579 @default.
- W4298132701 hasConcept C2780564542 @default.
- W4298132701 hasConcept C43617362 @default.
- W4298132701 hasConcept C518881349 @default.
- W4298132701 hasConcept C55493867 @default.
- W4298132701 hasConcept C71924100 @default.
- W4298132701 hasConceptScore W4298132701C126322002 @default.
- W4298132701 hasConceptScore W4298132701C178790620 @default.
- W4298132701 hasConceptScore W4298132701C179998833 @default.
- W4298132701 hasConceptScore W4298132701C181199279 @default.
- W4298132701 hasConceptScore W4298132701C185592680 @default.
- W4298132701 hasConceptScore W4298132701C2776923573 @default.
- W4298132701 hasConceptScore W4298132701C2779201268 @default.
- W4298132701 hasConceptScore W4298132701C2780091579 @default.
- W4298132701 hasConceptScore W4298132701C2780564542 @default.
- W4298132701 hasConceptScore W4298132701C43617362 @default.
- W4298132701 hasConceptScore W4298132701C518881349 @default.
- W4298132701 hasConceptScore W4298132701C55493867 @default.
- W4298132701 hasConceptScore W4298132701C71924100 @default.
- W4298132701 hasFunder F4320334764 @default.
- W4298132701 hasLocation W42981327011 @default.
- W4298132701 hasLocation W42981327012 @default.
- W4298132701 hasOpenAccess W4298132701 @default.
- W4298132701 hasPrimaryLocation W42981327011 @default.
- W4298132701 hasRelatedWork W1986395714 @default.
- W4298132701 hasRelatedWork W1991580513 @default.
- W4298132701 hasRelatedWork W2023243756 @default.
- W4298132701 hasRelatedWork W2026165519 @default.
- W4298132701 hasRelatedWork W2027081549 @default.
- W4298132701 hasRelatedWork W2086107997 @default.
- W4298132701 hasRelatedWork W2096641431 @default.
- W4298132701 hasRelatedWork W2348707366 @default.
- W4298132701 hasRelatedWork W2429301418 @default.
- W4298132701 hasRelatedWork W2907045507 @default.
- W4298132701 hasVolume "222" @default.
- W4298132701 isParatext "false" @default.
- W4298132701 isRetracted "false" @default.
- W4298132701 workType "article" @default.