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- W4298137912 abstract "Abuse and maltreatment have been shown to negatively impact the developing brain through the HPA-axis, the body’s central stress response system. Theoretically, similar pathophysiology occurs when children experience more moderate forms of stress (i.e., changing schools); however, evidence for this association is lacking. To address this question, the current study explored the effects of typical variations in stressful events on the development of the hippocampus, a brain region susceptible to stress. Data from a 3-year accelerated longitudinal sample of 79 4- and 6-year-old children were used to assess the impact of stressful events on the development of hippocampal subfield volumes and functional connectivity. In the 4-year-old cohort, stressful experiences were related to increased functional connectivity between the hippocampus and the insula, a region important for emotional processing. In the 6-year-old cohort, stressful experiences were related to smaller CA1 and CA2-4/DG subfield volumes. Results from analyses comparing cohorts showed that there was a significantly greater effect of stressful events on CA2-4/DG volume in 6- compared to 4-year-old children. Overall, these findings provide evidence of the impact of typical variations in stressful events on the structure and function of the hippocampus and highlight the region and time-dependent nature of these stress effects. They also highlight the importance of understanding how brain development is impacted by stress in all forms because stress-related alterations in hippocampal development have been linked to variations in cognitive processes (e.g., memory) and risk for psychopathology (e.g., major depressive disorder)." @default.
- W4298137912 created "2022-10-01" @default.
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- W4298137912 date "2022-09-29" @default.
- W4298137912 modified "2023-09-23" @default.
- W4298137912 title "Experience of typical variations in stressors impact hippocampal structure and functional connectivity in childhood" @default.
- W4298137912 doi "https://doi.org/10.31234/osf.io/t9yrq" @default.
- W4298137912 hasPublicationYear "2022" @default.
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