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- W4298138400 endingPage "3155" @default.
- W4298138400 startingPage "3137" @default.
- W4298138400 abstract "Abstract: Targeted protein degradation (TPD) strategies have become a new trend in drug discovery due to the capability of triggering the degradation of protein of interest (POI) selectively and effectively in recent decades. Particularly, the hydrophobic tag tethering degrader (HyTTD) has drawn a lot of attention and may offer a promising strategy for new drug research and development in the future. Herein, we will give an overview of the development of HyTTD, the structure-activity relationship (SAR) between HyTTD and linkers, HyTs, and ligand motifs, as well as the various HyTTDs targeting different targets, thus offering a rational strategy for the design of HyTTDs in further TPD drug discovery." @default.
- W4298138400 created "2022-10-01" @default.
- W4298138400 creator A5048179207 @default.
- W4298138400 creator A5056603093 @default.
- W4298138400 creator A5069674140 @default.
- W4298138400 creator A5089323741 @default.
- W4298138400 date "2023-08-01" @default.
- W4298138400 modified "2023-09-25" @default.
- W4298138400 title "Hydrophobic Tag Tethering Degradation, The Emerging Targeted Protein Degradation Strategy" @default.
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