FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298139261> ?p ?o ?g. }

• W4298139261 endingPage "88" @default.
• W4298139261 startingPage "88" @default.
• W4298139261 abstract "88 Background: Historically, US clinical trials have been shown to recruit disproportionately large percentages of White patients, raising concerns about the generalizability of clinical trial results to underrepresented racial minority patient populations. Because of this, the FDA has recently reiterated its guidance stating that clinical trials need to reflect the demographic distribution of the US. In this research, we sought to understand how participation of Black patients varies by therapeutic area and geography within the US. Methods: Studying patient-level clinical trial data from an industry-leading historical clinical trial data repository of over 8 million patients from 27,000 clinical trials, we assessed the racial composition of US interventional trials across indications from 2010 to 2021 which encompassed 433,822 clinical trial participants across 2,997 trials. We also analyzed participants’ racial composition within the subset of trials from three distinct therapeutic areas (i.e., oncology n = 118,194, cardiovascular n = 12,281, central nervous system n = 35,533) and distinct sites over the same period. Results: The racial distribution of clinical trial participants in the US across all therapeutic areas was 78% White, 15% Black, and 3% Asian. Within the three distinct therapeutic areas, the proportion of Black clinical trial participants varied, with oncology trials reporting 8.5% Black participants, cardiovascular trials reporting 15.3% Black participants, and central nervous system trials reporting 19.9% Black participants. Black participation also varied within a therapeutic area, depending on the indication, as well as by site, with individual sites contributing differently to the racial diversity of trials. Conclusions: Our analysis shows that US interventional trials enroll 15% Black participants, appearing consistent with the 2020 US Census, which estimates that 14.6% of Americans are Black. However, more granular analyses at the level of therapeutic area, indication and site suggest substantial variation in Black participation in clinical trials including a gap in Black representation in oncology trials vs. US Census estimates. This research suggests that aggregate estimates of racial enrollment may mask dramatic variation by other factors like granularity of disease area and geographic location. The study of historic clinical trial data may yield useful insights for accelerating diverse representation in clinical trials." @default.
• W4298139261 created "2022-10-01" @default.
• W4298139261 creator A5010839658 @default.
• W4298139261 creator A5014609806 @default.
• W4298139261 creator A5026659225 @default.
• W4298139261 creator A5028691985 @default.
• W4298139261 creator A5032244954 @default.
• W4298139261 creator A5079046632 @default.
• W4298139261 creator A5083219208 @default.
• W4298139261 creator A5088596153 @default.
• W4298139261 date "2022-10-01" @default.
• W4298139261 modified "2023-09-26" @default.
• W4298139261 title "How granularity of data matters in understanding and accelerating racial diversity in U.S. clinical trials." @default.
• W4298139261 doi "https://doi.org/10.1200/jco.2022.40.28_suppl.088" @default.
• W4298139261 hasPublicationYear "2022" @default.
• W4298139261 type Work @default.
• W4298139261 citedByCount "0" @default.
• W4298139261 crossrefType "journal-article" @default.
• W4298139261 hasAuthorship W4298139261A5010839658 @default.
• W4298139261 hasAuthorship W4298139261A5014609806 @default.
• W4298139261 hasAuthorship W4298139261A5026659225 @default.
• W4298139261 hasAuthorship W4298139261A5028691985 @default.
• W4298139261 hasAuthorship W4298139261A5032244954 @default.
• W4298139261 hasAuthorship W4298139261A5079046632 @default.
• W4298139261 hasAuthorship W4298139261A5083219208 @default.
• W4298139261 hasAuthorship W4298139261A5088596153 @default.
• W4298139261 hasConcept C126322002 @default.
• W4298139261 hasConcept C138496976 @default.
• W4298139261 hasConcept C144024400 @default.
• W4298139261 hasConcept C149923435 @default.
• W4298139261 hasConcept C15744967 @default.
• W4298139261 hasConcept C19165224 @default.
• W4298139261 hasConcept C27158222 @default.
• W4298139261 hasConcept C2781316041 @default.
• W4298139261 hasConcept C512399662 @default.
• W4298139261 hasConcept C535046627 @default.
• W4298139261 hasConcept C71924100 @default.
• W4298139261 hasConcept C74909509 @default.
• W4298139261 hasConceptScore W4298139261C126322002 @default.
• W4298139261 hasConceptScore W4298139261C138496976 @default.
• W4298139261 hasConceptScore W4298139261C144024400 @default.
• W4298139261 hasConceptScore W4298139261C149923435 @default.
• W4298139261 hasConceptScore W4298139261C15744967 @default.
• W4298139261 hasConceptScore W4298139261C19165224 @default.
• W4298139261 hasConceptScore W4298139261C27158222 @default.
• W4298139261 hasConceptScore W4298139261C2781316041 @default.
• W4298139261 hasConceptScore W4298139261C512399662 @default.
• W4298139261 hasConceptScore W4298139261C535046627 @default.
• W4298139261 hasConceptScore W4298139261C71924100 @default.
• W4298139261 hasConceptScore W4298139261C74909509 @default.
• W4298139261 hasIssue "28_suppl" @default.
• W4298139261 hasLocation W42981392611 @default.
• W4298139261 hasOpenAccess W4298139261 @default.
• W4298139261 hasPrimaryLocation W42981392611 @default.
• W4298139261 hasRelatedWork W1561459040 @default.
• W4298139261 hasRelatedWork W2407151074 @default.
• W4298139261 hasRelatedWork W2786100060 @default.
• W4298139261 hasRelatedWork W2883785577 @default.
• W4298139261 hasRelatedWork W2955570986 @default.
• W4298139261 hasRelatedWork W3016544133 @default.
• W4298139261 hasRelatedWork W3205549620 @default.
• W4298139261 hasRelatedWork W4246296440 @default.
• W4298139261 hasRelatedWork W4252522767 @default.
• W4298139261 hasRelatedWork W4294941257 @default.
• W4298139261 hasVolume "40" @default.
• W4298139261 isParatext "false" @default.
• W4298139261 isRetracted "false" @default.
• W4298139261 workType "article" @default.