Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298148907> ?p ?o ?g. }
- W4298148907 endingPage "103993" @default.
- W4298148907 startingPage "103993" @default.
- W4298148907 abstract "Aspergillus fumigatus and Pseudomonas aeruginosa biofilms are associated to the recalcitrant and persistent infections due to resistance to antimicrobials. Here, we evaluated the effect of antimicrobials on single and mixed biofilms of A. fumigatus and P. aeruginosa (carbapenem-resistant and susceptible strains) determining total biomass by crystal violet, cell viability by colony forming unit count, and microscopy. Polymyxin B (PMB) had the best action on P. aeruginosa biofilms inhibiting the biomass (2–4 μg/mL) and it was efficient reducing the viable bacterial cells. Amphotericin B (AMB) and caspofungin (CAS) were the best antifungal at inhibiting A. fumigatus biofilms and reducing fungal viability at concentration ≥1 and ≥ 16 μg/mL, respectively. In addition, CAS was able to significantly reduce P. aeruginosa viability in mixed biofilms. CAS combined with PMB also significantly reduced the mixed biofilm biomass and fungal and bacterial viability mainly against carbapenem-resistant bacterium. The light and fluorescence microscopy showed alterations on hyphae morphology and confirmed the increase of fungal and bacterial death cells after combined therapy of mixed biofilms. Taken together, our work showed that CAS alone and its combination with PMB showed better potential in reducing mixed biofilm biomass and fungal and bacterial viability, even for the carbapenem-resistant P. aeruginosa strain." @default.
- W4298148907 created "2022-10-01" @default.
- W4298148907 creator A5027799102 @default.
- W4298148907 creator A5033241636 @default.
- W4298148907 creator A5044776932 @default.
- W4298148907 creator A5075545813 @default.
- W4298148907 date "2023-01-01" @default.
- W4298148907 modified "2023-09-30" @default.
- W4298148907 title "Caspofungin alone or combined with polymyxin B are effective against mixed biofilm of Aspergillus fumigatus and carbapenem-resistant Pseudomonas aeruginosa" @default.
- W4298148907 cites W1599002996 @default.
- W4298148907 cites W1895204403 @default.
- W4298148907 cites W1930493764 @default.
- W4298148907 cites W1991004042 @default.
- W4298148907 cites W2055753580 @default.
- W4298148907 cites W2067122019 @default.
- W4298148907 cites W2080781202 @default.
- W4298148907 cites W2088330635 @default.
- W4298148907 cites W2096034349 @default.
- W4298148907 cites W2112677154 @default.
- W4298148907 cites W2123785844 @default.
- W4298148907 cites W2128824216 @default.
- W4298148907 cites W2149696039 @default.
- W4298148907 cites W2155327463 @default.
- W4298148907 cites W2164032940 @default.
- W4298148907 cites W2236839872 @default.
- W4298148907 cites W2297086543 @default.
- W4298148907 cites W2344481781 @default.
- W4298148907 cites W2418746400 @default.
- W4298148907 cites W2462098506 @default.
- W4298148907 cites W2521500024 @default.
- W4298148907 cites W2548444708 @default.
- W4298148907 cites W2603363139 @default.
- W4298148907 cites W2606696784 @default.
- W4298148907 cites W2787413609 @default.
- W4298148907 cites W2793135586 @default.
- W4298148907 cites W2883038680 @default.
- W4298148907 cites W2900258790 @default.
- W4298148907 cites W2943627940 @default.
- W4298148907 cites W2947248389 @default.
- W4298148907 cites W2947865901 @default.
- W4298148907 cites W3092615964 @default.
- W4298148907 cites W3110990819 @default.
- W4298148907 cites W3207485951 @default.
- W4298148907 doi "https://doi.org/10.1016/j.resmic.2022.103993" @default.
- W4298148907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36184018" @default.
- W4298148907 hasPublicationYear "2023" @default.
- W4298148907 type Work @default.
- W4298148907 citedByCount "0" @default.
- W4298148907 crossrefType "journal-article" @default.
- W4298148907 hasAuthorship W4298148907A5027799102 @default.
- W4298148907 hasAuthorship W4298148907A5033241636 @default.
- W4298148907 hasAuthorship W4298148907A5044776932 @default.
- W4298148907 hasAuthorship W4298148907A5075545813 @default.
- W4298148907 hasBestOaLocation W42981489071 @default.
- W4298148907 hasConcept C2777637488 @default.
- W4298148907 hasConcept C2779548794 @default.
- W4298148907 hasConcept C2779629538 @default.
- W4298148907 hasConcept C2779787849 @default.
- W4298148907 hasConcept C2780026444 @default.
- W4298148907 hasConcept C2780402444 @default.
- W4298148907 hasConcept C2780675486 @default.
- W4298148907 hasConcept C4937899 @default.
- W4298148907 hasConcept C501593827 @default.
- W4298148907 hasConcept C523546767 @default.
- W4298148907 hasConcept C54355233 @default.
- W4298148907 hasConcept C58123911 @default.
- W4298148907 hasConcept C86803240 @default.
- W4298148907 hasConcept C89423630 @default.
- W4298148907 hasConceptScore W4298148907C2777637488 @default.
- W4298148907 hasConceptScore W4298148907C2779548794 @default.
- W4298148907 hasConceptScore W4298148907C2779629538 @default.
- W4298148907 hasConceptScore W4298148907C2779787849 @default.
- W4298148907 hasConceptScore W4298148907C2780026444 @default.
- W4298148907 hasConceptScore W4298148907C2780402444 @default.
- W4298148907 hasConceptScore W4298148907C2780675486 @default.
- W4298148907 hasConceptScore W4298148907C4937899 @default.
- W4298148907 hasConceptScore W4298148907C501593827 @default.
- W4298148907 hasConceptScore W4298148907C523546767 @default.
- W4298148907 hasConceptScore W4298148907C54355233 @default.
- W4298148907 hasConceptScore W4298148907C58123911 @default.
- W4298148907 hasConceptScore W4298148907C86803240 @default.
- W4298148907 hasConceptScore W4298148907C89423630 @default.
- W4298148907 hasIssue "1-2" @default.
- W4298148907 hasLocation W42981489071 @default.
- W4298148907 hasLocation W42981489072 @default.
- W4298148907 hasOpenAccess W4298148907 @default.
- W4298148907 hasPrimaryLocation W42981489071 @default.
- W4298148907 hasRelatedWork W1493048381 @default.
- W4298148907 hasRelatedWork W1599002996 @default.
- W4298148907 hasRelatedWork W1965773128 @default.
- W4298148907 hasRelatedWork W2088330635 @default.
- W4298148907 hasRelatedWork W2408505898 @default.
- W4298148907 hasRelatedWork W2742754374 @default.
- W4298148907 hasRelatedWork W2920024053 @default.
- W4298148907 hasRelatedWork W2981449273 @default.
- W4298148907 hasRelatedWork W4221038791 @default.
- W4298148907 hasRelatedWork W4298148907 @default.
- W4298148907 hasVolume "174" @default.