Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298182229> ?p ?o ?g. }
- W4298182229 abstract "Abstract Recruitment of RNA polymerase II (Pol II) to promoter regions is essential for transcription. Despite conflicting evidence, the Pol II Pre-Initiation Complex (PIC) is often thought to be of uniform composition and assemble at all promoters via an identical mechanism. Here, we show using Drosophila melanogaster S2 cells as a model that promoter classes with distinct functions and initiation patterns function via PICs that display different compositions and dependencies: developmental promoter DNA readily associates with the canonical Pol II PIC, whereas housekeeping promoter DNA does not and instead recruit different factors such as DREF. Consistently, TBP and DREF are required by distinct sets of promoters, and TBP and its paralog TRF2 function at different promoter types, partly exclusively and partly redundantly. In contrast, TFIIA is required for transcription from all promoters, and we identify factors that can recruit and/or stabilize TFIIA at housekeeping promoters and activate transcription. We show that promoter activation by these factors is sufficient to induce the dispersed transcription initiation patterns characteristic of housekeeping promoters. Thus, different promoter classes direct distinct mechanisms of transcription initiation, which relate to different focused versus dispersed initiation patterns." @default.
- W4298182229 created "2022-10-01" @default.
- W4298182229 creator A5006214397 @default.
- W4298182229 creator A5014342884 @default.
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- W4298182229 creator A5052020232 @default.
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- W4298182229 creator A5066064710 @default.
- W4298182229 creator A5067625368 @default.
- W4298182229 creator A5077542208 @default.
- W4298182229 date "2022-10-01" @default.
- W4298182229 modified "2023-10-16" @default.
- W4298182229 title "Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns" @default.
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