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• W4298302095 endingPage "807" @default.
• W4298302095 startingPage "747" @default.
• W4298302095 abstract "Rituximab has been documented in the treatment of acute (≤ 3 days from admission), relapsed/refractory thrombotic thrombocytopenic purpura (TTP) and given as prophylaxis in selected cases to prevent acute relapse. The precise timing of rituximab in acute TTP has not been determined.To perform a retrospective analysis of rituximab use in a large TTP referral center over an 8-year period.We assessed response to treatment and outcome for all patients treated with rituximab, including 91 patients presenting with 104 episodes of acute TTP and 15 patients given rituximab as prophylaxis to prevent relapse. In the acute TTP group we assessed the benefit of giving early (≤ 3 days from admission) vs. later (> 3 days) rituximab.In acute de novoTTP, previously untreated with rituximab, rituximab was given ≤ 3 days from admission to 54 patients and > 3 days from admission to 32 patients. Earlier administration (≤ 3 days) was associated with faster attainment of remission (12 vs. 20 days, P< 0.001), fewer plasma exchanges (16 vs. 24, P = 0.03) and shorter hospital stay (16 vs. 23 days, P = 0.01). Eighty-two patients (95%) achieved complete remission within 14 days (4–52 days); four patients died acutely. Eleven out of 82 (13.4%) relapsed at a median of 24 months (4–49 months). Rituximab prophylaxis was associated with normalization of ADAMTS13 levels within 3 months in all but one case, with only one acute relapse at follow-up.Although limited by being retrospective and non-randomized, this study demonstrates the potential benefit of early administration of rituximab in acute TTP, and prophylactic use to prevent acute relapse." @default.
• W4298302095 created "2022-10-01" @default.
• W4298302095 creator A5003173488 @default.
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• W4298302095 date "1989-12-01" @default.
• W4298302095 modified "2023-09-25" @default.
• W4298302095 title "Pulmonary and Pleural Manifestations of Extrathoracic Malignancies" @default.
• W4298302095 cites W104357069 @default.
• W4298302095 cites W123231952 @default.
• W4298302095 cites W142912546 @default.
• W4298302095 cites W1481260705 @default.
• W4298302095 cites W1506003867 @default.
• W4298302095 cites W1509400195 @default.
• W4298302095 cites W1512841977 @default.
• W4298302095 cites W1530240629 @default.
• W4298302095 cites W1533161867 @default.
• W4298302095 cites W1533857881 @default.
• W4298302095 cites W1560128843 @default.
• W4298302095 cites W1561758716 @default.
• W4298302095 cites W1598490335 @default.
• W4298302095 cites W1662367799 @default.
• W4298302095 cites W1867002980 @default.
• W4298302095 cites W1870042613 @default.
• W4298302095 cites W1887353051 @default.
• W4298302095 cites W1922212549 @default.
• W4298302095 cites W1951007319 @default.
• W4298302095 cites W1964455546 @default.
• W4298302095 cites W1964624837 @default.
• W4298302095 cites W1964734845 @default.
• W4298302095 cites W1964846497 @default.
• W4298302095 cites W1965474903 @default.
• W4298302095 cites W1965644085 @default.
• W4298302095 cites W1965789580 @default.
• W4298302095 cites W1966833887 @default.
• W4298302095 cites W1967023478 @default.
• W4298302095 cites W1968301500 @default.
• W4298302095 cites W1968351468 @default.
• W4298302095 cites W1968616159 @default.
• W4298302095 cites W1969176764 @default.
• W4298302095 cites W1969927172 @default.
• W4298302095 cites W1970359064 @default.
• W4298302095 cites W1970880370 @default.
• W4298302095 cites W1971036790 @default.
• W4298302095 cites W1971475314 @default.
• W4298302095 cites W1971721468 @default.
• W4298302095 cites W1971781615 @default.
• W4298302095 cites W1971793304 @default.
• W4298302095 cites W1972271733 @default.
• W4298302095 cites W1972808394 @default.
• W4298302095 cites W1972974458 @default.
• W4298302095 cites W1973065847 @default.
• W4298302095 cites W1973915732 @default.
• W4298302095 cites W1974093039 @default.
• W4298302095 cites W1974219980 @default.
• W4298302095 cites W1974805778 @default.
• W4298302095 cites W1975126592 @default.
• W4298302095 cites W1977607685 @default.
• W4298302095 cites W1977712393 @default.
• W4298302095 cites W1978313011 @default.
• W4298302095 cites W1979544185 @default.
• W4298302095 cites W1979957665 @default.
• W4298302095 cites W1980027831 @default.
• W4298302095 cites W1980082823 @default.
• W4298302095 cites W1980560969 @default.
• W4298302095 cites W1980771989 @default.
• W4298302095 cites W1980979769 @default.
• W4298302095 cites W1981274480 @default.
• W4298302095 cites W1981541640 @default.
• W4298302095 cites W1982501154 @default.
• W4298302095 cites W1984508342 @default.
• W4298302095 cites W1984937897 @default.
• W4298302095 cites W1985402501 @default.
• W4298302095 cites W1985503055 @default.
• W4298302095 cites W1985600570 @default.
• W4298302095 cites W1986002491 @default.
• W4298302095 cites W1986012948 @default.
• W4298302095 cites W1986015369 @default.
• W4298302095 cites W1986023546 @default.
• W4298302095 cites W1986120963 @default.
• W4298302095 cites W1986465740 @default.
• W4298302095 cites W1986559772 @default.
• W4298302095 cites W1986960944 @default.
• W4298302095 cites W1987482593 @default.
• W4298302095 cites W1988058709 @default.
• W4298302095 cites W1988743060 @default.
• W4298302095 cites W1989710661 @default.
• W4298302095 cites W1989909971 @default.
• W4298302095 cites W1990422260 @default.
• W4298302095 cites W1991351007 @default.
• W4298302095 cites W1991636971 @default.
• W4298302095 cites W1992054036 @default.
• W4298302095 cites W1992113457 @default.
• W4298302095 cites W1992574665 @default.
• W4298302095 cites W1992644583 @default.
• W4298302095 cites W1994623919 @default.
• W4298302095 cites W1995053654 @default.

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