FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298325924> ?p ?o ?g. }

• W4298325924 endingPage "102806" @default.
• W4298325924 startingPage "102806" @default.
• W4298325924 abstract "Fed-batch culture of Chinese hamster ovary (CHO) cells remains the most commonly used method for producing biopharmaceuticals. Static CHO cell-line engineering approaches have incrementally improved productivity, growth and product quality through permanent knockout of genes with a negative impact on production, or constitutive overexpression of genes with a positive impact. However, during fed-batch culture, conditions (such as nutrient availability) are continually changing. Therefore, traits that are most beneficial during early-phase culture (such as high growth rate) may be less desirable in late phase. Unlike with static approaches, dynamic cell line engineering strategies can optimise such traits by implementing synthetic sense-and-respond programmes. Here, we review emerging synthetic biology tools that can be used to build dynamic, self-regulating CHO cells, capable of detecting intra-/extracellular cues and generating user-defined responses tailored to the stage-specific needs of the production process." @default.
• W4298325924 created "2022-10-02" @default.
• W4298325924 creator A5035091697 @default.
• W4298325924 creator A5036161341 @default.
• W4298325924 creator A5038739433 @default.
• W4298325924 date "2022-12-01" @default.
• W4298325924 modified "2023-10-12" @default.
• W4298325924 title "Synthetic biology approaches for dynamic CHO cell engineering" @default.
• W4298325924 cites W1688835773 @default.
• W4298325924 cites W1889987954 @default.
• W4298325924 cites W1964138634 @default.
• W4298325924 cites W1965813899 @default.
• W4298325924 cites W1967156547 @default.
• W4298325924 cites W1967240723 @default.
• W4298325924 cites W2006848863 @default.
• W4298325924 cites W2013971421 @default.
• W4298325924 cites W2026650987 @default.
• W4298325924 cites W2040587998 @default.
• W4298325924 cites W2050655839 @default.
• W4298325924 cites W2060464742 @default.
• W4298325924 cites W2061289922 @default.
• W4298325924 cites W2062410066 @default.
• W4298325924 cites W2069942860 @default.
• W4298325924 cites W2070961268 @default.
• W4298325924 cites W2084219873 @default.
• W4298325924 cites W2101749257 @default.
• W4298325924 cites W2102232272 @default.
• W4298325924 cites W2110279489 @default.
• W4298325924 cites W2115571948 @default.
• W4298325924 cites W2131566517 @default.
• W4298325924 cites W2131740110 @default.
• W4298325924 cites W2148650601 @default.
• W4298325924 cites W2149879897 @default.
• W4298325924 cites W2154571764 @default.
• W4298325924 cites W2162293690 @default.
• W4298325924 cites W2168458927 @default.
• W4298325924 cites W2171056307 @default.
• W4298325924 cites W2172134808 @default.
• W4298325924 cites W2176248123 @default.
• W4298325924 cites W2256857837 @default.
• W4298325924 cites W2273082455 @default.
• W4298325924 cites W2526887159 @default.
• W4298325924 cites W2578480980 @default.
• W4298325924 cites W2592640253 @default.
• W4298325924 cites W2597907100 @default.
• W4298325924 cites W2602851191 @default.
• W4298325924 cites W2615106780 @default.
• W4298325924 cites W2615233592 @default.
• W4298325924 cites W2791856011 @default.
• W4298325924 cites W2800956912 @default.
• W4298325924 cites W2803696525 @default.
• W4298325924 cites W2804352314 @default.
• W4298325924 cites W2804424677 @default.
• W4298325924 cites W2864786814 @default.
• W4298325924 cites W2900730496 @default.
• W4298325924 cites W2901060305 @default.
• W4298325924 cites W2911743301 @default.
• W4298325924 cites W2919310841 @default.
• W4298325924 cites W2947645884 @default.
• W4298325924 cites W2952851245 @default.
• W4298325924 cites W2953362829 @default.
• W4298325924 cites W2954763614 @default.
• W4298325924 cites W2971361428 @default.
• W4298325924 cites W2981811911 @default.
• W4298325924 cites W2999995333 @default.
• W4298325924 cites W3012358100 @default.
• W4298325924 cites W3016013842 @default.
• W4298325924 cites W3016541160 @default.
• W4298325924 cites W3046624515 @default.
• W4298325924 cites W3126547801 @default.
• W4298325924 cites W3153851923 @default.
• W4298325924 cites W3171327314 @default.
• W4298325924 cites W3175572973 @default.
• W4298325924 cites W3202178925 @default.
• W4298325924 cites W4207079907 @default.
• W4298325924 cites W4220969470 @default.
• W4298325924 cites W4224122484 @default.
• W4298325924 cites W4225471014 @default.
• W4298325924 cites W4280583590 @default.
• W4298325924 cites W993338644 @default.
• W4298325924 doi "https://doi.org/10.1016/j.copbio.2022.102806" @default.
• W4298325924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36194920" @default.
• W4298325924 hasPublicationYear "2022" @default.
• W4298325924 type Work @default.
• W4298325924 citedByCount "4" @default.
• W4298325924 countsByYear W42983259242022 @default.
• W4298325924 countsByYear W42983259242023 @default.
• W4298325924 crossrefType "journal-article" @default.
• W4298325924 hasAuthorship W4298325924A5035091697 @default.
• W4298325924 hasAuthorship W4298325924A5036161341 @default.
• W4298325924 hasAuthorship W4298325924A5038739433 @default.
• W4298325924 hasConcept C127413603 @default.
• W4298325924 hasConcept C139719470 @default.
• W4298325924 hasConcept C150903083 @default.
• W4298325924 hasConcept C162324750 @default.
• W4298325924 hasConcept C175656101 @default.
• W4298325924 hasConcept C183696295 @default.
• W4298325924 hasConcept C191908910 @default.

• next