Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298395487> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4298395487 endingPage "iv9" @default.
- W4298395487 startingPage "iv9" @default.
- W4298395487 abstract "Abstract AIMS Discrepancies exist in the use of stereotactic radiotherapy (SRT) for patients with 10 or more brain metastases. Concerns include multiple metastases being associated with poor survival and the lack of prospective data. We analysed survival outcomes of these patients in a multi-centre cohort. METHOD We performed a retrospective cohort study of 511 consecutive patients from three SRT centres treated for brain metastases between January 2010 - August 2021, censored in January 2022. We assessed survival post-SRT of patients with ≥10 metastases against a matched group of 5-9 and 1-4 metastases using the logrank test for statistical testing. We used a multivariate Cox model to assess the relationship between overall survival and: number of metastases; total volume; primary malignancy; use of systemic anti-cancer therapies with intracranial penetrance; controlled extracranial disease. Results with p-values <0.05 were considered significant. RESULTS Survival data was available for all patients, and for 85-100% of factors in multivariate analysis. 63 patients had ≥10 metastases (median 19). Median survival was 13.3 months, compared with 15.1 and 19.0 months for the 5-9 and 1-4 metastasis groups respectively. Differences were not statistically significant (p-value 0.14). Increasing volume of disease (HR 1.05 [1.01-1.09], p-value: 0.01), non-small cell lung cancer (HR 3.5 [1.35-9.09] p-value: 0.01) and use of systemic anti-cancer therapy with intracranial penetrance (HR 0.239 [0.105-0.547] p-value: <0.01) had a statistically significant effect on survival in multivariate analysis. CONCLUSION Carefully selected patients with multiple metastases have acceptable survival outcomes following SRT and this approach should be more widely considered." @default.
- W4298395487 created "2022-10-02" @default.
- W4298395487 creator A5027714865 @default.
- W4298395487 creator A5079749832 @default.
- W4298395487 date "2022-10-01" @default.
- W4298395487 modified "2023-09-27" @default.
- W4298395487 title "Survival Outcomes of Stereotactic Radiotherapy for Ten or More Brain Metastases" @default.
- W4298395487 doi "https://doi.org/10.1093/neuonc/noac200.040" @default.
- W4298395487 hasPublicationYear "2022" @default.
- W4298395487 type Work @default.
- W4298395487 citedByCount "0" @default.
- W4298395487 crossrefType "journal-article" @default.
- W4298395487 hasAuthorship W4298395487A5027714865 @default.
- W4298395487 hasAuthorship W4298395487A5079749832 @default.
- W4298395487 hasBestOaLocation W42983954871 @default.
- W4298395487 hasConcept C10515644 @default.
- W4298395487 hasConcept C121608353 @default.
- W4298395487 hasConcept C126322002 @default.
- W4298395487 hasConcept C143998085 @default.
- W4298395487 hasConcept C167135981 @default.
- W4298395487 hasConcept C2776256026 @default.
- W4298395487 hasConcept C2776907518 @default.
- W4298395487 hasConcept C2778164965 @default.
- W4298395487 hasConcept C2779013556 @default.
- W4298395487 hasConcept C2779399171 @default.
- W4298395487 hasConcept C2780387249 @default.
- W4298395487 hasConcept C38180746 @default.
- W4298395487 hasConcept C50382708 @default.
- W4298395487 hasConcept C509974204 @default.
- W4298395487 hasConcept C66339696 @default.
- W4298395487 hasConcept C71924100 @default.
- W4298395487 hasConcept C72563966 @default.
- W4298395487 hasConceptScore W4298395487C10515644 @default.
- W4298395487 hasConceptScore W4298395487C121608353 @default.
- W4298395487 hasConceptScore W4298395487C126322002 @default.
- W4298395487 hasConceptScore W4298395487C143998085 @default.
- W4298395487 hasConceptScore W4298395487C167135981 @default.
- W4298395487 hasConceptScore W4298395487C2776256026 @default.
- W4298395487 hasConceptScore W4298395487C2776907518 @default.
- W4298395487 hasConceptScore W4298395487C2778164965 @default.
- W4298395487 hasConceptScore W4298395487C2779013556 @default.
- W4298395487 hasConceptScore W4298395487C2779399171 @default.
- W4298395487 hasConceptScore W4298395487C2780387249 @default.
- W4298395487 hasConceptScore W4298395487C38180746 @default.
- W4298395487 hasConceptScore W4298395487C50382708 @default.
- W4298395487 hasConceptScore W4298395487C509974204 @default.
- W4298395487 hasConceptScore W4298395487C66339696 @default.
- W4298395487 hasConceptScore W4298395487C71924100 @default.
- W4298395487 hasConceptScore W4298395487C72563966 @default.
- W4298395487 hasIssue "Supplement_4" @default.
- W4298395487 hasLocation W42983954871 @default.
- W4298395487 hasOpenAccess W4298395487 @default.
- W4298395487 hasPrimaryLocation W42983954871 @default.
- W4298395487 hasRelatedWork W1987683595 @default.
- W4298395487 hasRelatedWork W2066530402 @default.
- W4298395487 hasRelatedWork W2166561562 @default.
- W4298395487 hasRelatedWork W2357428483 @default.
- W4298395487 hasRelatedWork W2376493575 @default.
- W4298395487 hasRelatedWork W2419775784 @default.
- W4298395487 hasRelatedWork W2559969777 @default.
- W4298395487 hasRelatedWork W2587755700 @default.
- W4298395487 hasRelatedWork W4250577720 @default.
- W4298395487 hasRelatedWork W4252476369 @default.
- W4298395487 hasVolume "24" @default.
- W4298395487 isParatext "false" @default.
- W4298395487 isRetracted "false" @default.
- W4298395487 workType "article" @default.