Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298395709> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4298395709 endingPage "iv18" @default.
- W4298395709 startingPage "iv17" @default.
- W4298395709 abstract "Abstract AIMS ‘CyberKnife’ stereotactic radiosurgery (SRS) is increasingly being used as a treatment for spinal haemangioblastoma to avoid complex surgery, especially in patients with multi-focal tumours associated with von Hippel-Lindau syndrome (VHL). Here we present the outcomes of patients treated in our centre. METHOD Retrospective review of patients treated at St Bartholomew’s Hospital, London. Assessment of radiological response was based upon RECIST criteria. The development of a symptomatic new or worsening cyst was included in the definition of progression when determining overall tumour control. Solid and overall tumour control rates were calculated using the Kaplan-Meier method. RESULTS 14 tumours in 10 patients were included. 70% of patients were male and 90% had VHL. 9 (64%) tumours had an associated cyst. The median (IQR) age at treatment was 45.5 (43.5 – 53). The median gross tumour volume was 0.355cc. Patients received a mean marginal prescribed dose of 9.6Gy in a single fraction (mean central dose 14Gy) – dose constrained by spinal cord tolerance. Mean follow up was 15.4 months. 7 patients’ symptoms improved or were stable and 3 worsened. Radiologically, 11 (78.6%) of tumours were stable or regressed, and 3 (21.4%) progressed. The 1-year solid tumour and overall tumour control rates were 92.3% and 75.7% respectively. All patients were alive at most recent follow up. 2 patients developed grade 1 adverse related events. CONCLUSION SRS is a safe and effective treatment modality for spinal haemangioblastoma. Further prospective randomised trials with longer follow up are required to determine the optimum management strategy." @default.
- W4298395709 created "2022-10-02" @default.
- W4298395709 creator A5010592192 @default.
- W4298395709 creator A5013519100 @default.
- W4298395709 creator A5023856227 @default.
- W4298395709 creator A5056293873 @default.
- W4298395709 creator A5057298397 @default.
- W4298395709 creator A5063195392 @default.
- W4298395709 creator A5084469246 @default.
- W4298395709 creator A5086021155 @default.
- W4298395709 date "2022-10-01" @default.
- W4298395709 modified "2023-10-18" @default.
- W4298395709 title "CyberKnife Stereotactic Radiosurgery for Spinal Haemangioblastoma: A Single Centre Experience" @default.
- W4298395709 doi "https://doi.org/10.1093/neuonc/noac200.078" @default.
- W4298395709 hasPublicationYear "2022" @default.
- W4298395709 type Work @default.
- W4298395709 citedByCount "0" @default.
- W4298395709 crossrefType "journal-article" @default.
- W4298395709 hasAuthorship W4298395709A5010592192 @default.
- W4298395709 hasAuthorship W4298395709A5013519100 @default.
- W4298395709 hasAuthorship W4298395709A5023856227 @default.
- W4298395709 hasAuthorship W4298395709A5056293873 @default.
- W4298395709 hasAuthorship W4298395709A5057298397 @default.
- W4298395709 hasAuthorship W4298395709A5063195392 @default.
- W4298395709 hasAuthorship W4298395709A5084469246 @default.
- W4298395709 hasAuthorship W4298395709A5086021155 @default.
- W4298395709 hasBestOaLocation W42983957091 @default.
- W4298395709 hasConcept C118552586 @default.
- W4298395709 hasConcept C126322002 @default.
- W4298395709 hasConcept C126838900 @default.
- W4298395709 hasConcept C141071460 @default.
- W4298395709 hasConcept C167135981 @default.
- W4298395709 hasConcept C188816634 @default.
- W4298395709 hasConcept C197934379 @default.
- W4298395709 hasConcept C2776651944 @default.
- W4298395709 hasConcept C2780387249 @default.
- W4298395709 hasConcept C2780597408 @default.
- W4298395709 hasConcept C2780775167 @default.
- W4298395709 hasConcept C509974204 @default.
- W4298395709 hasConcept C71924100 @default.
- W4298395709 hasConceptScore W4298395709C118552586 @default.
- W4298395709 hasConceptScore W4298395709C126322002 @default.
- W4298395709 hasConceptScore W4298395709C126838900 @default.
- W4298395709 hasConceptScore W4298395709C141071460 @default.
- W4298395709 hasConceptScore W4298395709C167135981 @default.
- W4298395709 hasConceptScore W4298395709C188816634 @default.
- W4298395709 hasConceptScore W4298395709C197934379 @default.
- W4298395709 hasConceptScore W4298395709C2776651944 @default.
- W4298395709 hasConceptScore W4298395709C2780387249 @default.
- W4298395709 hasConceptScore W4298395709C2780597408 @default.
- W4298395709 hasConceptScore W4298395709C2780775167 @default.
- W4298395709 hasConceptScore W4298395709C509974204 @default.
- W4298395709 hasConceptScore W4298395709C71924100 @default.
- W4298395709 hasIssue "Supplement_4" @default.
- W4298395709 hasLocation W42983957091 @default.
- W4298395709 hasOpenAccess W4298395709 @default.
- W4298395709 hasPrimaryLocation W42983957091 @default.
- W4298395709 hasRelatedWork W1971665703 @default.
- W4298395709 hasRelatedWork W1994448744 @default.
- W4298395709 hasRelatedWork W2047959643 @default.
- W4298395709 hasRelatedWork W2153808903 @default.
- W4298395709 hasRelatedWork W2223519418 @default.
- W4298395709 hasRelatedWork W3016104851 @default.
- W4298395709 hasRelatedWork W3125196731 @default.
- W4298395709 hasRelatedWork W3137251891 @default.
- W4298395709 hasRelatedWork W3208827450 @default.
- W4298395709 hasRelatedWork W4235011506 @default.
- W4298395709 hasVolume "24" @default.
- W4298395709 isParatext "false" @default.
- W4298395709 isRetracted "false" @default.
- W4298395709 workType "article" @default.