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- W4298529507 abstract "Metastasis, the primary cause of morbidity and mortality for most cancer patients, can be challenging to model preclinically in mice. Few spontaneous metastasis models are available. Thus, the experimental metastasis model involving tail-vein injection of suitable cell lines is a mainstay of metastasis research. When cancer cells are injected into the lateral tail-vein, the lung is their preferred site of colonization. A potential limitation of this technique is the accurate quantification of the metastatic lung tumor burden. While some investigators count macrometastases of a pre-defined size and/or include micrometastases following sectioning of tissue, others determine the area of metastatic lesions relative to normal tissue area. Both of these quantification methods can be exceedingly difficult when the metastatic burden is high. Herein, we demonstrate an intravenous injection model of lung metastasis followed by an advanced method for quantifying metastatic tumor burden using image analysis software. This process allows for investigation of multiple end-point parameters, including average metastasis size, total number of metastases, and total metastasis area, to provide a comprehensive analysis. Furthermore, this method has been reviewed by a veterinary pathologist board-certified by the American College of Veterinary Pathologists (SEK) to ensure accuracy." @default.
- W4298529507 created "2022-10-02" @default.
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- W4298529507 date "2020-05-20" @default.
- W4298529507 modified "2023-10-17" @default.
- W4298529507 title "Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells" @default.
- W4298529507 doi "https://doi.org/10.3791/61270-v" @default.
- W4298529507 hasPublicationYear "2020" @default.
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