Matches in SemOpenAlex for { <https://semopenalex.org/work/W4298841272> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4298841272 endingPage "5" @default.
- W4298841272 startingPage "1051" @default.
- W4298841272 abstract "Liver cirrhosis may be accompanied by osteoporosis and, rarely, osteomalacia. Normal liver function is required for normal digestion and absorption of calcium-containing nutrients. The liver plays an important role for the metabolisation of vitamin D: the 25-hydroxylation takes place in the liver. However, the respective enzymatic capacity is not limited by liver diseases except for almost complete liver insufficiency. Therefore, true hypovitaminosis D only rarely plays a role in hepatic osteopenia, but direct toxic effects on bone forming cells (osteoblasts) are discussed: e.g. by bile salts. Coexisting hypogonadism leads to further bone loss. Patients with primary biliary cirrhosis in part present with osteoporosis and fractures. Bone histology reveals normal resorption, but decreased formation. Calcitropic hormones are generally normal. Chronic alcoholism induces the same histologic picture in bone, i.e. normal resorption and diminished formation. These changes are reversible after abstinence and as long as of cirrhosis has not yet developed. Patients undergoing liver transplantation due to end stage liver insufficiency including cirrhosis present with diminished bone mass before receiving a new liver, and they show further bone loss after the transplantation due to immunosuppressive treatment including glucocorticoids. There is no specific treatment of bone loss or osteoporosis due to liver cirrhosis. Preventive efforts should be devoted to the avoidance of suboptimal calcium and vitamin D supply, immobilization, and hypogonadism. Fluorides may increase bone mass after liver transplantation--perhaps they are also useful in liver cirrhosis. Antiresorption agents like calcitonins or bisphosphonates may be cautiously tried." @default.
- W4298841272 created "2022-10-02" @default.
- W4298841272 creator A5040791382 @default.
- W4298841272 date "1994-09-20" @default.
- W4298841272 modified "2023-09-26" @default.
- W4298841272 title "[Osteoporosis]." @default.
- W4298841272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7939067" @default.
- W4298841272 hasPublicationYear "1994" @default.
- W4298841272 type Work @default.
- W4298841272 citedByCount "0" @default.
- W4298841272 crossrefType "journal-article" @default.
- W4298841272 hasAuthorship W4298841272A5040791382 @default.
- W4298841272 hasConcept C124490489 @default.
- W4298841272 hasConcept C126322002 @default.
- W4298841272 hasConcept C134018914 @default.
- W4298841272 hasConcept C146562846 @default.
- W4298841272 hasConcept C2776541429 @default.
- W4298841272 hasConcept C2776886416 @default.
- W4298841272 hasConcept C2777083390 @default.
- W4298841272 hasConcept C2777214474 @default.
- W4298841272 hasConcept C2778049618 @default.
- W4298841272 hasConcept C2779609443 @default.
- W4298841272 hasConcept C2780366471 @default.
- W4298841272 hasConcept C2911091166 @default.
- W4298841272 hasConcept C2992208098 @default.
- W4298841272 hasConcept C673006 @default.
- W4298841272 hasConcept C71924100 @default.
- W4298841272 hasConcept C90924648 @default.
- W4298841272 hasConceptScore W4298841272C124490489 @default.
- W4298841272 hasConceptScore W4298841272C126322002 @default.
- W4298841272 hasConceptScore W4298841272C134018914 @default.
- W4298841272 hasConceptScore W4298841272C146562846 @default.
- W4298841272 hasConceptScore W4298841272C2776541429 @default.
- W4298841272 hasConceptScore W4298841272C2776886416 @default.
- W4298841272 hasConceptScore W4298841272C2777083390 @default.
- W4298841272 hasConceptScore W4298841272C2777214474 @default.
- W4298841272 hasConceptScore W4298841272C2778049618 @default.
- W4298841272 hasConceptScore W4298841272C2779609443 @default.
- W4298841272 hasConceptScore W4298841272C2780366471 @default.
- W4298841272 hasConceptScore W4298841272C2911091166 @default.
- W4298841272 hasConceptScore W4298841272C2992208098 @default.
- W4298841272 hasConceptScore W4298841272C673006 @default.
- W4298841272 hasConceptScore W4298841272C71924100 @default.
- W4298841272 hasConceptScore W4298841272C90924648 @default.
- W4298841272 hasIssue "38" @default.
- W4298841272 hasLocation W42988412721 @default.
- W4298841272 hasOpenAccess W4298841272 @default.
- W4298841272 hasPrimaryLocation W42988412721 @default.
- W4298841272 hasRelatedWork W1985019823 @default.
- W4298841272 hasRelatedWork W1989067987 @default.
- W4298841272 hasRelatedWork W1990936130 @default.
- W4298841272 hasRelatedWork W2034626585 @default.
- W4298841272 hasRelatedWork W2061776718 @default.
- W4298841272 hasRelatedWork W2086037419 @default.
- W4298841272 hasRelatedWork W2088891312 @default.
- W4298841272 hasRelatedWork W2166196230 @default.
- W4298841272 hasRelatedWork W2350254144 @default.
- W4298841272 hasRelatedWork W2807907342 @default.
- W4298841272 hasVolume "83" @default.
- W4298841272 isParatext "false" @default.
- W4298841272 isRetracted "false" @default.
- W4298841272 workType "article" @default.