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- W4298843148 abstract "Linkage maps are used to identify the location of genes responsible for traits and diseases. New sequencing techniques have created opportunities to substantially increase the density of genetic markers. Such revolutionary advances in technology have given rise to new challenges, such as creating high-density linkage maps. Current multiple testing approaches based on pairwise recombination fractions are underpowered in the high-dimensional setting and do not extend easily to polyploid species. We propose to construct linkage maps using graphical models either via a sparse Gaussian copula or a nonparanormal skeptic approach. Linkage groups (LGs), typically chromosomes, and the order of markers in each LG are determined by inferring the conditional independence relationships among large numbers of markers in the genome. Through simulations, we illustrate the utility of our map construction method and compare its performance with other available methods, both when the data are clean and contain no missing observations and when data contain genotyping errors and are incomplete. We apply the proposed method to two genotype datasets: barley and potato from diploid and polypoid populations, respectively. Our comprehensive map construction method makes full use of the dosage SNP data to reconstruct linkage map for any bi-parental diploid and polyploid species. We have implemented the method in the R package netgwas." @default.
- W4298843148 created "2022-10-02" @default.
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- W4298843148 date "2017-10-03" @default.
- W4298843148 modified "2023-09-24" @default.
- W4298843148 title "De novo construction of polyploid linkage maps using discrete graphical models" @default.
- W4298843148 doi "https://doi.org/10.48550/arxiv.1710.01063" @default.
- W4298843148 hasPublicationYear "2017" @default.
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