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• W4298966941 abstract "No AccessJournal of UrologyInvestigative Urology1 Jan 1996A Potential Use of a Monoclonal Antibody to Placental Alkaline Phosphatase (PLAP) to Detect Lymph Node Metastases of Seminoma Kiyoshi Koshida, Tadao Uchibayashi, Hajime Yamamoto, Kunihiko Yokoyama, and Kazuyuki Hirano Kiyoshi KoshidaKiyoshi Koshida More articles by this author , Tadao UchibayashiTadao Uchibayashi More articles by this author , Hajime YamamotoHajime Yamamoto More articles by this author , Kunihiko YokoyamaKunihiko Yokoyama More articles by this author , and Kazuyuki HiranoKazuyuki Hirano More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66656-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To evaluate the ability of monoclonal antibodies against alkaline phosphatase (AL-P) for tumor immunolocalization in nude mice. Materials and Methods: Two monoclonal antibodies against placental alkaline phosphatase (PLAP) and liver alkaline phosphatase (LAP) were intravenously administered to nude mice bearing AL-P producing HeLa Hep 2 tumors. Sera and tumors from 65 patients with testicular germ cell tumors were examined for PLAP levels. Results: Levels of PLAP or LAP in the HeLa xenografts were shown to be comparable to levels of PLAP in seminomas, including lymph node metastases, or nonseminomas, respectively. A biodistribution study showed that the percentage of the injected dose of I-125 labelled anti-PLAP in the xenografts was rather constant at around 7 percent until 7 days after injection, while the percentage of the injected dose of I-125 labelled anti-LAP MAb decreased with time as in other tissues which do not contain significant amounts of PLAP or LAP. On scintiscan, the xenografts in nude mice were distinctly visualized at 7 days after injection of anti-PLAP MAb. Conclusions: These data may support the potential use of the anti-PLAP MAb for the immunodetection of lymph node metastases of seminoma. References 1 : Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein. Cancer1980; 45: 2500. Google Scholar 2 : The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma. Br. J. Cancer1987; 55: 657. Google Scholar 3 : Placental-like alkaline phosphatase in seminoma. Urol. Res.1990; 18: 87. Google Scholar 4 : The role of alkaline phosphatase isoenzymes as tumor markers for testicular germ cell tumors. J. Urol.1991; 146: 57. Abstract, Google Scholar 5 : Immunopathology of alkaline phosphatase isozymes in seminoma. Urol. Int.1993; 50: 33. Google Scholar 6 : Tumour and cellular localization by use of monoclonal and polyclonal antibodies to placental alkaline phosphatase. Br. J. Cancer1984; 49: 123. Google Scholar 7 : A highly sensitive assay method for human placental alkaline phosphatase involving a monoclonal antibody bound to a paper disk. Anal. Biochem.1986; 154: 624. Google Scholar 8 : Specific assay for human alkaline phosphatase isozymes. Clin. Chim. Acta1987; 166: 265. Google Scholar 9 : The preparation of sup 131 I-labeled human growth hormone of high specific radioactivity. Biochem. J.1963; 89: 114. Google Scholar 10 : Radiolocalisation and imaging of stable HPLAP-transfected MO4 tumours with monoclonal antibodies and fragments. Br. J. Cancer1991; 64: 1060. Google Scholar 11 : Immunoscintigraphy with sup 131 I-labelled H17E2 monoclonal antibody compared with conventional lymphangiography and computed tomography in the detection of metastases in patients with testicular germ cell tumours. Br. J. Cancer1990; 62: 74. Google Scholar 12 : Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms. Cancer Res.1986; 46: 3183. Google Scholar 13 : Antibody-guided radiolocalisation of tumours in patients with testicular or ovarian cancer using two radio-iodinated monoclonal antibodies to placental alkaline phosphatase. Br. J. Radiol.1986; 59: 117. Google Scholar Departments of Urology and Nuclear Medicine, School of Medicine, Kanazawa University and Gifu Pharmaceutical University, Kanazawa, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKoshida K, Yokoyama K, Uchibayashi T, Yamamoto H, Hirano K and Namiki M (2018) Factors Contributing to Imaging of Xenografts Using Anti-Placental Alkaline Phosphatase Monoclonal AntibodyJournal of Urology, VOL. 157, NO. 5, (1941-1945), Online publication date: 1-May-1997. Volume 155Issue 1January 1996Page: 337-341 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Kiyoshi Koshida More articles by this author Tadao Uchibayashi More articles by this author Hajime Yamamoto More articles by this author Kunihiko Yokoyama More articles by this author Kazuyuki Hirano More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W4298966941 title "A Potential Use of a Monoclonal Antibody to Placental Alkaline Phosphatase (PLAP) to Detect Lymph Node Metastases of Seminoma" @default.
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