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• W4299286143 abstract "Abstract Memory transformation is increasingly acknowledged in theoretical accounts of systems consolidation, yet how memory quality and neural representation change over time and how schemas influence this process remains unclear. We examined the behavioral quality and neural representation of schema-congruent and incongruent object-scene pairs retrieved across 10-minutes and 72-hours using fMRI. When a congruent schema was available, memory became coarser over time, aided by post-encoding coupling between the anterior hippocampus and medial prefrontal cortex (mPFC). Only schema-congruent representations were integrated in the mPFC over time, and were organized according to schematic context. In the hippocampus, pattern similarity changed across 72-hours such that the posterior hippocampus represented specific details and the anterior hippocampus represented the general context of specific memories, irrespective of congruency. Our findings suggest schemas are used as a scaffold to facilitate neocortical integration of congruent information, and illustrate evolution in hippocampal organization of detailed contextual memory over time." @default.
• W4299286143 created "2022-10-02" @default.
• W4299286143 creator A5060057153 @default.
• W4299286143 creator A5085708001 @default.
• W4299286143 date "2022-10-02" @default.
• W4299286143 modified "2023-10-14" @default.
• W4299286143 title "Schemas provide a scaffold for neocortical integration of new memories over time" @default.
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