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- W4299306908 abstract "In 39 patients who received haloperidol regularly we measured plasma concentrations of haloperidol glucuronide (HAL-GL), reduced haloperidol glucuronide (RHAL-GL), haloperidol (HAL), reduced haloperidol (RHAL), and HAL reductase activity in red blood cells. Plasma HAL-GL concentrations were significantly higher than HAL, RHAL, or RHAL-GL concentrations. Concentration ratios of total glucuronide to nonglucuronide and RHAL/HAL ratios were calculated as indices of glucuronidation and reduction capacity in each patient. The plasma glucuronidation ratios showed a significant negative correlation (r = −0.63, p < 0.001) with the dose, while the reduction ratios showed a positive correlation (r = 0.75, p < 0.001). No correlations were found between the HAL reductase activity in red blood cells and either the dose or RHAL/HAL. Based on these findings we suggest that glucuronidation of HAL is the major metabolic pathway of HAL in humans and its activity is important in determining steady-state plasma HAL concentrations. Glucuronidation may also be a major contributing factor in the interindividual variability of HAL metabolism." @default.
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- W4299306908 date "1992-06-01" @default.
- W4299306908 modified "2023-10-05" @default.
- W4299306908 title "Haloperidol Metabolism in Psychiatric Patients" @default.
- W4299306908 doi "https://doi.org/10.1097/00004714-199206000-00004" @default.
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